Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future ….
Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future …. Adv Pharmacol. 2017;79:35-66 Authors: Rash LD Abstract pH is one of the most strictly controlled parameters in mammalian physiology. An extracellular pH of ~7.4 is crucial for normal physiological processes, and perturbations to this have profound effects on cell function. Acidic microenvironments occur in many physiological and pathological conditions, including inflammation, bone remodeling, ischemia, trauma, and intense synaptic activity. Cells exposed to these conditions respond in different ways, from tumor cells that thrive to neurons that are either suppressed or hyperactivated, often fatally. Acid-sensing ion channels (ASICs) are primary pH sensors in mammals and are expressed widely in neuronal and nonneuronal cells. There are six main subtypes of ASICs in rodents that can form homo- or heteromeric channels resulting in many potential combinations. ASICs are present and activated under all of the conditions mentioned earlier, suggesting that they play an important role in how cells respond to acidosis. Compared to many other ion channel families, ASICs were relatively recently discovered-1997-and there is a substantial lack of potent, subtype-selective ligands that can be used to elucidate their structural and functional properties. In this chapter I cover the history of ASIC channel pharmacology, which began before the proteins were even identified, and describe the curr...
CONCLUSION: The small amount of evidence that is currently available suggests that presbycusis is underdiagnosed and under- treated in Germany. Early detection by physicians of all specialties, followed in each case by a specialized differential diagnostic evaluation, is a desirable goal. PMID: 31196393 [PubMed - in process]
Authors: Herold J, Bauersachs R PMID: 31196392 [PubMed - in process]
Authors: Bahra M, Geisel D, Müller T PMID: 31196391 [PubMed - in process]
Authors: Beck H PMID: 31196390 [PubMed - in process]
Sports Rehabilitation ("Rehabilitationssport") Is Effective in Improving Motor Function. Dtsch Arztebl Int. 2019 Apr 26;116(17):298 Authors: Krakor S, Jakob E PMID: 31196389 [PubMed - in process]
Authors: Brons F PMID: 31196388 [PubMed - in process]
Authors: Eichhorn L PMID: 31196387 [PubMed - in process]
Authors: Straube E PMID: 31196386 [PubMed - in process]
Authors: Leidel BA, Dormann H, Busch HJ, Kluge S PMID: 31196385 [PubMed - in process]
CONCLUSION: The causes of visual impairment are manifold. Loss of vision is often the combined effect of multiple pathological factors. The etiology of visual impair- ment is thus a more complex matter than is commonly assumed. PMID: 31196384 [PubMed - in process]