Author response: Early start of DOAC after ischemic stroke: Risk of intracranial hemorrhage and recurrent events

We thank Prof. Kawada for his interest in our article.1 We agree that larger patient cohorts more accurately estimate the risk of intracranial hemorrhage (ICH) from direct, non–vitamin K antagonist oral anticoagulants (DOACs). However, the definition of ICH is crucial. In our study we looked at symptomatic ICH (sICH) only, and observed only 1 patient with sICH.1 In contrast, the cited study of Cappellari et al.2 looked at both sICH and asymptomatic ICH: Of the 7 patients with any ICH after DOAC start, only 1 had sICH. Therefore, the rates of sICH were comparable between the 2 studies.

Source: Neurology - May 22, 2017 Category: Neurology Authors: Seiffge, D. J., De Marchis, G. M. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research