Pneumonia can Cause Clozapine Intoxications: A Case Report

Since the 1970s it was thought that respiratory infections, including pneumonia, may inhibit cytochrome P450 1A2 (CYP1A2) because they decrease theophylline clearance and theophylline metabolism is mediated by CYP1A2 inhibition.1 The mechanism was not completely understood, but it was thought that the release of cytokines during the infection decrease the activity and synthesis of CYP1A2.2 Therefore, Shilalukey et al.3 suggested that when a child taking theophylline develops an upper respiratory infection, the theophylline dose should be decreased almost by half.

Source: Psychosomatics - May 17, 2017 Category: Psychiatry & Psychology Authors: Can-Jun Ruan, Xue-Yang Zhen, Xin-Liang Ge, Chuan-Yue Wang, Wei Guo, Yi-Lang Tang, Wen-Biao Li, Jose de Leon Source Type: research