PLGA nanoparticles as chlorhexidine-delivery carrier to resin-dentin adhesive interface

Resin-dentin bonding is achieved through dentin demineralization to expose the underlying collagen-fibrils that facilitate resin-permeation into the filigree of mineral-deficit collagen-meshwork forming the transitional resin-dentin hybrid-interface and resin-tags inside dentinal-tubules [1]. Several endogenous dentin-bound matrix metalloproteinases (MMPs) and/or bacterial enzymes were identified to participate in the breakdown of naked collagen-fibrils, drastically affecting the mechanical and structural integrity [2,3].
Source: Dental Materials - Category: Materials Science Authors: Source Type: research