KAIST team identifies the novel molecular signal for triggering septic shock

(The Korea Advanced Institute of Science and Technology (KAIST)) Professor Seyun Kim's team from KAIST reported the mechanism by which cellular signaling transduction network is exquisitely controlled in mediating innate immune response such as sepsis by the enzyme IPMK (Inositol polyphosphate multikinase) essential for inositol biosynthesis metabolism.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Authors: Briegel J, Huge V, Möhnle P PMID: 30023091 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Publication date: Available online 19 July 2018Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): Nisha Crouser, Azeem Tariq Malik, Laura S. Phieffer, Thuan V. Ly, Safdar N. Khan, Carmen E. QuatmanAbstractIntroductionPre-operative urinary tract infection (UTI) may be associated with a high rate of complications following surgeries. Few studies have investigated the clinical impact of a pre-operative UTI on post-operative outcomes following surgeries for hip-fracture in geriatric patients.MethodsThe 2015–2016 ACS-NSQIP database was queried for patients undergoing hip fracture surgery using CPT-Codes for Tot...
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Publication date: Available online 25 May 2018Source: Journal of Hospital InfectionAuthor(s): I. Yeo, L.K. Kim, S.O. Park, S.C. WongSummaryBackgroundWhile the utilization of transcatheter aortic valve replacement (TAVR) for patients with severe aortic stenosis has been increasing, in-hospital infective endocarditis (IE) following TAVR has not been well described.AimTo identify in-hospital IE following TAVR.MethodsAll patients who underwent TAVR between 2012 and 2014 were identified using the National Inpatient Sample database. Multi-variate logistic regression was performed to identify the predictors of in-hospital IE afte...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
Condition:   Shock, Septic Interventions:   Drug: Combined Vitamin C and Stress-Dose Hydrocortisone;   Drug: Placebo plus placebo Sponsors:   University of Athens;   General Hospital of Nikaia “Saint Panteleimon”;   Naval Hospital, Athens Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This journal article outlines how sepsis is the body's systemic response to infection and is a serious health care concern that affects neonatal, pediatric, and adult populations worldwide. Severe sepsis and septic shock are still associated with high mortality rates despite improvements in the management of infectious processes. The cellular processes that occur as a result of the inflammatory response in sepsis, including impaired perfusion and microcirculatory coagulation, can lead to organ system dysfunction. Early recognition of sepsis can help prompt treatment to improve patient care. Current pediatric guidelines emp...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
This article discusses the new SSC treatment guidelines, changes in the sepsis bundle interventions, and the Sepsis-3 definitions and tools, all of which enable nurses to improve patient outcomes through timely collaborative action.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Abstract Approximately one third of protein therapeutics are produced in E. coli, targeting a wide variety of diseases. However, due to immune recognition of endotoxin (a lipid component in the E. coli cell membrane), these protein products must be extensively purified before application to avoid adverse reactions such as septic shock. E. coli-based cell-free protein synthesis (CFPS), which has emerged as a promising platform for the development and production of enhanced protein therapeutics, provides a unique opportunity to remove endotoxins prior to protein expression due to its open environment and the absence...
Source: Biotechnology Journal - Category: Biotechnology Authors: Tags: Biotechnol J Source Type: research
This study assessed the microbiology, clinical syndromes, and outcomes of oncologic patients with viridans group streptococci (VGS) isolated from blood cultures between January 1st, 2013 and December 31st, 2016 in a referral hospital in Mexico using the Bruker MALDI Biotyper. Antimicrobial sensitivity was determined using BD Phoenix 100 according to CLSI M100 standards. Clinical information was obtained from medical records and descriptive analysis was performed.Forty-three patients were included, 22 females and 21 males, aged 42 ± 17 years. Twenty (46.5%) patients had hematological cancer and 23 (53.5%) a solid...
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
CONCLUSION: Patients arrived very sick and displayed poor survival after deceased donor transplantation.
Source: Clinics - Category: General Medicine Source Type: research
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