KAIST team identifies the novel molecular signal for triggering septic shock
(The Korea Advanced Institute of Science and Technology (KAIST)) Professor Seyun Kim's team from KAIST reported the mechanism by which cellular signaling transduction network is exquisitely controlled in mediating innate immune response such as sepsis by the enzyme IPMK (Inositol polyphosphate multikinase) essential for inositol biosynthesis metabolism.
Authors: Wu P, Kong L, Li J Abstract The aim of the present study was to investigate the role of microRNA (miR)-494-3p in myocardial injury in patients with septic shock and the underlying mechanism. A total of 22 patients with sepsis and 17 patients with septic shock were included in the present study. In addition, 20 healthy subjects were recruited as the control group. Peripheral blood was collected from all subjects and a rat cardiomyocyte model of myocardial injury was constructed. Reverse transcription-quantitative polymerase chain reaction was used to measure miR-494-3p expression, while cell counting kit-8 ...
Publication date: Available online 22 February 2019Source: Journal of Critical CareAuthor(s): Sheldon Magder
Sepsis-induced myocardial dysfunction is associated with poor outcomes, but traditional measurements of systolic function such as left ventricular ejection fraction (LVEF) do not directly correlate with prognosis. Global longitudinal strain (GLS) utilizing speckle-tracking echocardiography (STE) could be a better marker of intrinsic left ventricular (LV) function, reflecting myocardial deformation rather than displacement and volume changes. The authors sought to investigate the prognostic value of GLS in patients with sepsis and/or septic shock. Worse GLS (less negative) values are associated with higher mortality in pati...
The abdomen is the second most common source of sepsis and is associated with unacceptably high morbidity and mortality. Recently, the essential definitions of sepsis and septic shock were updated (Third International Consensus Definitions for Sepsis and Septic Shock, Sepsis-3) and modified. The purpose of this review is to provide an overview of the changes introduced by Sepsis-3 and the current state of the art regarding the treatment of abdominal sepsis.
The authors performed a systematic review and meta-analysis of studies of children with severe sepsis and septic shock to elucidate the patterns of CFRs in developing and developed countries over time. They also described factors associated with CFRs. Despite the declining trend of pediatric severe sepsis and septic shock CFRs, the disparity between developing and developed countries persists. Further characterizations of vulnerable populations and collaborations between developed and developing countries are warranted to reduce the burden of pediatric sepsis globally.
J Knee Surg DOI: 10.1055/s-0039-1677790Compared with nonelective total knee arthroplasties (TKAs), elective procedures have more time for preoperative planning, which allows for potentially improved patient optimization, risk factor modification, and patient education. The purpose of this study was to (1) determine nationwide trends in operative times and (2) evaluate associations between surgery type, elective or nonelective, with respect to (a) operative times, (b) length of stay (LOS), (c) discharge dispositions, (d) 30-day postoperative complications, (e) reoperations, and (f) readmissions. The American College of Surg...
A peripheral perfusion resuscitation strategy was not superior to the standard lactate-level testing currently used in patients with early septic shock in the five-country ANDROMEDA-SHOCK trial.Medscape Medical News
Condition: Septic Shock Interventions: Drug: ketamine full dose; Drug: Midazolam; Drug: Normal saline; Drug: ketamine half dose; Drug: Lidocaine Sponsor: Cairo University Not yet recruiting
Endocrinology and issues related to the role of hormones in critical care medicine remain a dominant component of physiologic investigations, pathophysiologic manipulation, and treatment in patients admitted to intensive care units (ICUs) worldwide. As an example, only in the last 12 months, three major multicenter phase 3 randomized controlled trials (RCTs) have been published, which involved the assessment of hormonal therapy (hydrocortisone and angiotensin II) in patients with septic shock.1–5
This randomized trial compares the effects of resuscitation strategies targeting normalization of capillary refill time vs normalization or decrease of serum lactate levels on 28-day mortality among patients with septic shock.