Extracranial Aneurysms in 2 Patients with Autosomal Recessive Polycystic Kidney Disease

We present 2 ARPKD patients with extracranial vascular abnormalities: a young man with infrarenal aortic and iliac artery aneurysms complicated by dissection and a teenage girl with multiple splenic and gastric artery aneurysms and arterial vascular malformations. These cases raise the question of whether vascular integrity and development may be impaired in ARPKD, perhaps through molecular mechanisms overlapping with ADPKD. This possibility is supported by studies in mice that show ARPKD gene expression in the walls of large blood vessels.Case Rep Nephrol Dial 2017;7:34 –42
Source: Case Reports in Nephrology and Dialysis - Category: Urology & Nephrology Source Type: research