Swallowing Disorders in Schizophrenia

AbstractDisorders of swallowing are poorly characterized but quite common in schizophrenia. They are a source of considerable morbidity and mortality in this population, generally as a result of either acute asphyxia from airway obstruction or more insidious aspiration and pneumonia. The death rate from acute asphyxia may be as high as one hundred times that of the general population. Most swallowing disorders in schizophrenia seem to fall into one of two categories, changes in eating and swallowing due to the illness itself and changes related to psychotropic medications. Behavioral changes related to the illness are poorly understood and often involve eating too quickly or taking inappropriately large boluses of food. Iatrogenic problems are mostly related to drug-induced extrapyramidal side effects, including drug-induced parkinsonism, dystonia, and tardive dyskinesia, but may also include xerostomia, sialorrhea, and changes related to sedation. This paper will provide an overview of common swallowing problems encountered in patients with schizophrenia, their pathophysiology, and management. While there is a scarcity of quality evidence in the literature, a thorough history and examination will generally elucidate the predominant problem or problems, often leading to effective management strategies.
Source: Dysphagia - Category: Speech Therapy Source Type: research

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Publication date: Available online 21 February 2019Source: NeuroscienceAuthor(s): Guillermina Tellez-Merlo, Julio Cesar Morales-Medina, Israel Camacho-Ábrego, Ismael Juárez-Díaz, Patricia Aguilar-Alonso, Fidel de la Cruz, Tommaso Iannitti, Gonzalo FloresAbstractSchizophrenia is a severe mental disorder with numerous etiological susceptibilities. Maternal infection is a key risk factor for schizophrenia. Prenatal lipopolysaccharide (LPS) infection stimulates cytokine production that affects brain development. In the present study, we aimed to investigate the effect of prenatal LPS injection at gestation...
Source: Neuroscience - Category: Neuroscience Source Type: research
Condition:   Pneumococcal Pneumonia Intervention:   Behavioral: Pharmacist Vaccine Education Sponsor:   Virginia Commonwealth University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pneumonia;   Hypoxemia Intervention:   Device: Solar-powered oxygen Sponsors:   University of Alberta;   Global Health Uganda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Pneumococcal Pneumonia Intervention:   Behavioral: Pharmacist Vaccine Education Sponsor:   Virginia Commonwealth University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pneumonia;   Hypoxemia Intervention:   Device: Solar-powered oxygen Sponsors:   University of Alberta;   Global Health Uganda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we describe the use of clozapine to treat 10 offenders with chronic, repetitive self-injury refractory to other medications and behavioral therapies. The primary diagnosis for all 10 offenders was a personality disorder. Eight of the 10 inmates allowed weekly blood draws and took medication regularly (approximately 95% adherence), whereas two inmates discontinued treatment within the first two weeks. For these eight patients, we compared the number of in-house urgent care visits and outside emergency room visits related to SIB for the six-month periods before and after treatment with clozapine. After initiat...
Source: Journal of the American Academy of Psychiatry and the Law - Category: Medical Law Tags: J Am Acad Psychiatry Law Source Type: research
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Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 22 February 2019Source: Microbes and InfectionAuthor(s): Olga Kotelnikova, Alexander Alliluev, Alexei Zinchenko, Larisa Zhigis, Yuri Prokopenko, Elena Nokel, Olga Razgulyaeva, Vera Zueva, Marina Tokarskaya, Natalia Yastrebova, Elena Gordeeva, Tatyana Melikhova, Elena Kaliberda, Lev RumshAbstractImmunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including N. meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits i...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Authors: Souza ROD, Borges AA, Bonelli MA, Dupas G Abstract OBJECTIVE: To know the composition and functioning of the social support used by the family of children with pneumonia. METHODS: A qualitative study was carried out with fourteen families of children under five years old hospitalized for pneumonia, coming from regions of greater social vulnerability in a city in the state of São Paulo, from November 2015 to May 2016. The theoretical reference used was the Calgary Family Assessment Model, and the Bardin Thematic Content Analysis was used as method. RESULTS: The nuclear family and the extended...
Source: Revista gaucha de enfermagem EENFUFRGS - Category: Nursing Tags: Rev Gaucha Enferm Source Type: research
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