Investigating the role of fibrinogen and iron in inflammatory demyelination using combined high-resolution mri and histopathology in marmoset experimental autoimmune encephalomyelitis (s50.008)

Conclusions:In conclusion, our results show that fibrinogen is a reliable marker of the early, active stage of EAE lesion development, whereas iron is a late marker and as such is unlikely to result directly from oligodendrocyte lysis.Disclosure: Dr. Lee has nothing to disclose. Dr. Ha has nothing to disclose. Dr. Luciano has nothing to disclose. Dr. Leibovitch has nothing to disclose. Dr. Lefeuvre has nothing to disclose. Dr. Sati has nothing to disclose. Dr. Schindler has nothing to disclose. Dr. Akassoglou has nothing to disclose. Dr. Silva has nothing to disclose. Dr. Jacobson has nothing to disclose. Dr. Reich has received research support from Vertex Pharmaceuticals.

Source: Neurology - April 17, 2017 Category: Neurology Authors: Lee, N., Ha, S.-K., Luciano, N., Leibovitch, E., Lefeuvre, J., Sati, P., Schindler, M., Akassoglou, K., Silva, A., Jacobson, S., Reich, D. Tags: MS Novel Therapeutics and Animal Models Source Type: research