Intra Individual Variability in Reaction Time Is Sensitive Across the Lifespan in Multiple Sclerosis (P4.352)

Conclusions:IIV in reaction time tasks may be used as a sensitive measure of performance variability in patients with MS and is related to cognitive performance as well. IIV is impaired in MS across the lifespan, including pediatric patients. IIV is a novel and sensitive marker of cognitive involvement in patients with MS, and may predict future cognitive decline as in other diseases.Study Supported by: The Lourie Center for Pediatric Multiple Sclerosis, the Department of Defense, and the National Multiple Sclerosis Society.Disclosure: Dr. Pau has nothing to disclose. Dr. Shaw has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Kasschau has nothing to disclose. Dr. Song has nothing to disclose. Dr. Krupp has received licensing and/or royalty fees from Johnson and Johnson, AbbVie, and Grifols. Dr. Charvet has received personal compensation for activities with Biogen as a consultant. Dr. Charvet holds stock and/or stock options with Johnson & Johnson. Dr. Charvet has received research support from Novartis and Biogen.
Source: Neurology - Category: Neurology Authors: Tags: Cognitive Impairment in Multiple Sclerosis: Clinical and MRI Correlates Source Type: research