Increasing Antibiotic Resistance in Shigella spp. in NYC Increasing Antibiotic Resistance in Shigella spp. in NYC

A new report of shigellosis cases in New York City provides insight into the increasing resistance to antibiotics commonly prescribed to treat the infection.Emerging Infectious Diseases
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: Infectious Diseases Journal Article Source Type: news

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Abstract Biological denitrification is a promising and green technology for air pollution control. To investigate the nitric oxide reductase (NOR) that dominates NO reduction efficiency in biological purification, the heterologous prokaryotic expression system of the norB gene, which encodes the core peptide of the catalytic reduction structure in the NOR from Achromobacter denitrificans strain TB, was constructed in Escherichia coli BL21 (DE3). Results showed that the 1218 bp-long norB gene was expressed at the highest level under 1.0 mM IPTG for 5 h at 30 °C, and the relative expression a...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Did you know diabetes affects your mental health? From depression to relationship problems or mood swings, too much or too little glucose (sugar) circulating in the blood can trigger behavior and thought patterns that may seem unrelated to how much insulin is released by your pancreas. Out of control glucose levels influence how you feel and make decisions, your beliefs and, yes, your attitude, a very necessary component of your overall care.  The U.S. Centers for Disease Control and Prevention (CDC) states less than half the number of people with diabetes who have depression get treated, which leads to worsening stat...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Mental Health and Wellness Comorbidities Diabetes Drug Interactions Nutrition Source Type: blogs
Bacteremia is an uncommon complication associated with Shigella infections. What are the risk factors for this rare infection?Emerging Infectious Diseases
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: Infectious Diseases Journal Article Source Type: news
Human α-defensins are 3- to 5-kDa disulfide-bridged peptides with a multitude of antimicrobial activities and immunomodulatory functions. Recent studies show that human enteric α-defensin 5 (HD5), a host defense peptide important for intestinal homeostasis and innate immunity, aids the highly infectious enteropathogen Shigella in breaching the intestinal epithelium in vitro and in vivo. Whether and how HD5 influences Shigella infection of resident macrophages following its invasion of the intestinal epithelium remain poorly understood. Here, we report that HD5 greatly promoted phagocytosis of Shigella by macrop...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research
In conclusion, the mouse pharyngeal colonization model is an affordable and accessible experimental system that allows a broader group of research groups to test the importance of their findings in an in vivo model. There is a great deal of overlap between the bacterial and immune factors found to be important in human and murine pharyngeal colonization. Although MHC-II humanized mice could prove useful in answering certain questions, the use of inbred mouse lines appears to be sufficient for evaluation of most questions, both related to bacterial factors and the host immune response. However, when promising treatments or ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
Publication date: December 2017 Source:The Lancet Global Health, Volume 5, Issue 12 Author(s): Kirkby D Tickell, Rebecca L Brander, Hannah E Atlas, Jeffrey M Pernica, Judd L Walson, Patricia B Pavlinac Background Shigella infections are a leading cause of diarrhoeal death among children in low-income and middle-income countries. WHO guidelines reserve antibiotics for treating children with dysentery. Reliance on dysentery for identification and management of Shigella infection might miss an opportunity to reduce Shigella-associated morbidity and mortality. We aimed to systematically review and evaluate Shigella-associated...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Shigella infection is becoming increasingly resistant to certain antimicrobial agents. What's the best course of action for this high-risk population?Emerging Infectious Diseases
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: Infectious Diseases Journal Article Source Type: news
Shigella flexneri is an emerging pathogen in men who have sex with men (MSM); recent outbreaks related to sexual practices have been noted in this population in the UK and other developed countries. While the majority of cases of shigellosis present with gastroenteritis, some vulnerable patients with underlying immunosuppression can develop complications like bacteraemia and may present atypically as an acute surgical emergency. This case report highlights such a case of S. flexneri bacteraemia in a man who had sex with men.
Source: International Journal of STD and AIDS - Category: Global & Universal Authors: Tags: Case reports Source Type: research
Conclusions HIV-positive MSM infected with S flexneri 3a used social media to meet sexual partners for unprotected sex mainly at sex parties. The potential for the transmission of S flexneri, HIV and other infections is clear. MSM need to be aware of the effect that chemsex drugs have on their health.
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Editor's choice, Drugs: infectious diseases, HIV/AIDS, HIV / AIDS, Gonorrhoea, HIV infections, Health education Epidemiology Source Type: research
More News: Dysentery | Gastroenteritis | HIV AIDS | Infectious Diseases