VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase

Conclusions:
The FFAT-like motifs we identified in FAF1 and ASNA1 demonstrate that sequences containing a single phenylalanine residue with the consensus (D/E)(D/E)FEDAx(D/E) are also proficient to mediate interaction with VAPB.Our findings indicate that the repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase complexes such as p97/FAF1 and ASNA1/TRC.

Source: BMC Biology - Latest articles - May 29, 2014 Category: Biology Authors: Yorann BaronPatrick PedrioliKshitiz TyagiClare JohnsonNicola WoodDaniel FountaineMelanie WightmanGabriela Alexandru Source Type: research