Some haematological parameters of albino mice experimentally inoculated with Trypanosoma brucei brucei after administration of Halofantrine hydrochloride, chloroquine and diaminazine aceturate

AbstractTrypanosomosis has been a menace. When animals become infected with trypanosomosis, their physiology is altered leading to haematological aberrations. The comparative effects of Halofantrine chloride (Halfan), chloroquine and diaminazine aceturate (DA) were experimentally investigated in the treatment ofTrypanosoma brucei brucei infected albino mice. This is to know whether Halfan and chloroquine can provide alternatives to diaminazine aceturate. White albino mice experimentally infected withT. brucei brucei which were separately treated 7  days post infection with Halfan at 100 mg/kg body weight as a single dose orally, chloroquine phosphate at 0.12 mg/kg body weight, administered intraperitoneally (IP) and DA given IP at 3.5 mg/kg body weight and the last group served as the untreated control. There was a slight depression of th e packed cell volume (PCV) after infection of all the groups. However, following treatment, there was significant rise (P 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Publication date: Available online 14 November 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): S. Gentile, F. Strollo, E. Satta, T. Della-Corte, C. Romano, G. Guarino, Nefrocenter Research Study Group: Nephrologists, Diabetologists, NursesSummaryDiabetes Mellitus (DM) is the most common cause of renal failure and ESRD all over the world, and often requires an individualized insulin treatment regimen. Malnutrition, depression-related eating behavior changes, high on-off-dialysis day-to-day glycemic variability and frequent hypoglycemic events occurring during or immediately after dialy...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 14 November 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Mahdieh Sedighi Pashaki, Jamal Asad Mezel, Zahra Mokhtari, Reza Ghanei Gheshlagh, Parisa Shahbazi Hesabi, Taban Nematifard, Soore KhakiAbstractDepression is one of the most common psychiatric disorders in patients with diabetes, which can exacerbate and accelerate adverse diabetes complaints by reducing self-care behaviors and medication adherence. The purpose of this study is to estimate the prevalence of depression in Iranian patients with diabetes. The search was conducted in the database...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
This study aimed to investigate the risk behaviors of adolescents with T1D and the effect of orthorexic eating behaviors (OEB) on glycemic control (GC). Methods: This cross-sectional study was conducted with 107 adolescents with T1D who were between 13-18 years of age and attended high school. The risk behavior scale (RBS) and orthorexic behavior scale (ORTO-11) were administered to the participants. A high RBS score indicates risky behavior; a low ORTO-11 score suggests a tendency to OEB. At the same time, participants were tested for GC and categorized as optimal GC (HbA1c ≤7%) or poor GC (HbA1c>7%). Result...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
ConclusionOur results highlight rumination as a two-edged sword that reflects a disease-specific neuropathology but also points to a functionality of depressive symptoms with evolutionary meaning.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Insomnia can be a disruptive condition that affects your entire life. When you aren’t able to sleep at night, it can negatively impact issues in almost every area of your life and well-being. If you are taking sleeping pills or are thinking about starting to take sleeping pills, make sure you know as much as possible about all the sleeping pill side effects. What Are Sleeping Pills and How Do They Work? Sleeping pills are used to treat insomnia. According to the National Sleep Foundation, insomnia is described as difficulty falling asleep or staying asleep, even when a person has the chance to do so. People with ins...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction to Pharmaceuticals Sleep healthy sleep insomnia sleep aids sleep and chronobiology laboratory sleep deprivation sleep disorder treatment sleep disorders sleep duration sleep habits sleeping sleeping pills sleeplessness Source Type: blogs
Adding a single infusion of ketamine to a program of mindfulness-based relapse prevention (MBRP) may promote abstinence in patients who use cocaine, according to a study published in the NovemberAmerican Journal of Psychiatry.In a five-week trial conducted by Elias Dakwar, M.D., of Columbia University Medical Center and colleagues, 55 patients who met theDSM-IV criteria for cocaine dependence were randomized to receive a 40-minute intravenous infusion of either ketamine or midazolam (a preoperative sedative). They received their infusions on the second day of a five-day hospitalization in a psychiatric research unit. Durin...
Source: Psychiatr News - Category: Psychiatry Tags: abstinence cocaine dependence Elias Dakwar ketamine M.D. midazolam mindfulness-based relapse prevention Source Type: research
Abstract Leonurus cardiaca L. (motherwort) is a perennial herb, native to Asia and southeastern Europe, with widespread global occurrence in present days. The plant was historically used as cardiotonic and for treating gynaecological afflictions (such as amenorrhea, dysmenorrhea, menopausal anxiety, or postpartum depression). Although its use in oriental and occidental medicine is relatively well documented, the recent progress registered raises the need for an update of the Medicines Agency assessment report on Leonurus cardiaca L., herba (2010). The current study presents the progress made within the 2010-2018 t...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In conclusion, many factors are of high importance in the analysis of food choices, and the results obtained using the FaceReader 6 technique are very promising for food-mood relation analysis. We suggest that mood has a strong link with the choice of food. PMID: 31119155 [PubMed - indexed for MEDLINE]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion: Raphe nuclei degeneration, related alterations in neurotransmitter system activities and functional brain connectivity might be related to neurobiology of depression. PMID: 31724476 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Conclusions: This study provides evidence that depressive symptoms are prevalent among outpatients of general hospitals. Moreover, younger age, alcohol consumption and sleep disturbance may potentially be useful for targeted screening and prevention for outpatients with depression seen in general hospitals.KeypointsThe prevalence of self-reported depressive symptoms is common in outpatients in clinical settings.Younger age, current alcohol drinking and sleep disturbance are the associated risk factors for depression in outpatient population.Alcohol prevention and sleep quality improvement need to be incorporated into strat...
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
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