332 CD69+CD103+ CD8 resident memory T cells with the potential of producing interleukin-17 are enriched in both lesional and non- lesional skin of psoriasis patients

Interleukin-17-producing T cells, besides dendritic cells, keratinocytes and neutrophils, play an important role in psoriasis biology. Contribution of CD4 T cells to disease manifestation has been investigated more in details than that of CD8 T cells, so that the role of CD8 T cells has been poorly established. In our present study, T cells were isolated from twelve lesional and non-lesional skin specimens in psoriasis patients and nine normal skin specimens from the patients undergoing skin tumor resection and skin grafting, and their phenotypical differences were compared.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research