Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca 2+ release in atrial cardiomyocytes

Conclusions</div>Our results support the concept of bidirectional interaction between RyRs and InsP₃Rs (i.e. Ca²⁺sparks and Ca²⁺puffs) in atrial myocytes. We conclude that highly efficient InsP₃ dependent SR-Ca²⁺flux constitute the main mechanism of functional crosstalk between InsP₃Rs and RyRs resulting in more Ca²⁺sensitized RyRs to trigger subsequent Ca²⁺-induced Ca²⁺release activation. In this way, bidirectional local interaction of both SR-Ca²⁺release channels may contribute to the shaping of global Ca²⁺transients and thereby to contractility in cardiac myocytes.</span>

Source: Cardiovascular Research - February 24, 2017 Category: Cardiology Source Type: research