The Dynamics of Gastric Emptying and Self-Reported Feelings of Satiation Are Better Predictors Than Gastrointestinal Hormones of the Effects of Lipid Emulsion Structure on Fat Digestion in Healthy Adults--A Bayesian Inference Approach [Methodology and Mathematical Modeling]

Conclusions: This work indicates that evenly dispersed, stable, small-emulsion droplets within the stomach lead to prolonged gastric distension, longer ghrelin suppression, and accelerated fat sensing (cholecystokinin and PPY), triggering prolonged feelings of satiation. It suggests that the effects of emulsion instability and droplet size on energy consumption are best studied by assessing changes in gastric emptying and ratings of satiation rather than changes in venous hormone profiles. This trial was registered at clinicaltrials.gov as NCT01253005.

Source: Journal of Nutrition - April 3, 2017 Category: Nutrition Authors: Steingoetter, A., Buetikofer, S., Curcic, J., Menne, D., Rehfeld, J. F., Fried, M., Schwizer, W., Wooster, T. J. Tags: Methodology and Mathematical Modeling Source Type: research