Diagnosis of Muscular Dystrophy in a 6-Week-Old With Jaundice
No abstract available
ConclusionOur work revealed that B. javanica and Bruceine D correct the SMN2 splicing defect and improve the symptoms of SMA in mice. These resources will provide another possibility for development of a plant-derived SMA drug candidate.
Conclusions The authors conclude that sympathetic blocks may be therapeutic in patients with complex regional pain syndrome regardless of preprocedure limb temperatures. The effects of sympathetic blocks do not predict the success of spinal cord stimulation.
In conclusion, the present study uncovered a novel regulatory mechanism of β2‑AR‑activated autophagy in NB cell growth and provides a novel potential therapeutic approach for treating NB by targeting autophagy and the β2‑AR pathway. PMID: 31524241 [PubMed - as supplied by publisher]
CONCLUSIONS: While both sound types had a positive impact on many dimensions of tinnitus, only the broadband noise was associated with a reduction in blood pressure. These results are consistent with a complex interaction between sound and tinnitus and suggest a multifactorial basis to sound therapy that includes a reduction in arousal. PMID: 31519289 [PubMed - in process]
This study investigated changes in sleep architecture during ASV treatment in HFrEF patients.MethodsA retrospective analysis of polysomnographic datasets for 30 ASV-treated patients with stable HFrEF and moderate-to-severe CSA was performed, including blinded analyses of total sleep time (TST), and percentage of REM and non-REM sleep (stages N1-N3).ResultsFollow-up was 109 ± 32 days; mean device usage was 6.0 ± 1.1 h/day. During ASV there was reduction of N1 (34 ± 20%/TST to 13 ± 5%/TST, p
Parkinson disease (PD), pure autonomic failure (PAF), and multiple system atrophy (MSA) are characterized by intra-cerebral deposition of the protein alpha-synuclein and are termed synucleinopathies. Lewy body synucleinopathies involve decreased cardiac sympathetic innervation and functional abnormalities in residual noradrenergic terminals. This observational, retrospective, cohort study describes long-term trends in indices of cardiac sympathetic innervation and function in synucleinopathies.
This study aimed to determine the role of the endocardial endothelium (EE) in the cardiac β-adrenergic (β-AR) remodeling at the early phase of endotoxemic shock.Main methodsRats received either lipopolysaccharide (LPS) or saline (control) intravenously. Three hours later, β-AR cardiac contractility was evaluated on papillary muscles with or without a functional EE.Key findingsIsoproterenol-induced contractility was strongly increased in papillary muscles from LPS rats. A similar increase was observed with a β1-AR stimulation, whereas β2-AR and β3-AR produced similar contractility in control an...
Authors: Suwal B, Bajimaya S, Bernstein PS PMID: 31512983 [PubMed - as supplied by publisher]
ConclusionsOur results suggest that burn patients have a sensitivity dysfunction in postburned skin areas. The use of QST could be considered the technique to determine the sensitivity of burned patients. Although, more high-quality studies should to be done.
Publication date: Available online 13 September 2019Source: International OrthodonticsAuthor(s): Yingzhi Gu, Rui Zhuang, Xianju Xie, Dongliang Zhang, Yuxing BaiSummaryObjectiveElectric resistance heat treatment procedures are performed by most orthodontists; however, the effects of electrothermal treatment on the mechanical properties, surface morphology, phase transition, colour and arch width of stainless steel archwires remain controversial and are worthy of investigation.Materials and methodsStainless steel archwires (0.017 × 0.025 and 0.019 × 0.025 inches) were heat-treated using a spot...