Surface Engineered Dendrimers in Sirna Delivery and Gene Silencing.

CONCLUSION: Thus, surface modified dendrimers render a complete pack which offers increased siRNA loading, increased transfection and permeability, efficient targeting, endosomal escape and protecting siRNA from degradation by RNase and other such enzymes. The objective of this manuscript is to provide different approaches currently available for surface modifications of dendrimers and their overall effect on transfection ability of siRNA to target tissues.
PMID: 28292248 [PubMed - as supplied by publisher]

Source: Current Pharmaceutical Design - March 13, 2017 Category: Drugs & Pharmacology Authors: Tambe V, Thakkar S, Raval N, Sharma D, Kalia K, Tekade RK Tags: Curr Pharm Des Source Type: research