Stereoselective Synthesis of Novel Adamantane Derivatives with High Potency Against Rimantadine-Resistant Influenza A Virus Strains

Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00331E, CommunicationNikolai Kuznetsov, Rabdan Tikhov, Ivan Godovikov, Michael Medvedev, Konstantin Lyssenko, Elena Burtseva, Elena Kirillova, Yurii N. Bubnov A series of (R)- and (S)-isomers of new adamantane-substituted heterocycles (1,3-oxazinan-2-one, piperidine-2,4-dione, piperidine-2-one and piperidine) with potent activity against rimantadine-resistant strains of Influenza A virus were synthesized through the transformation... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - March 10, 2017 Category: Molecular Biology Authors: Nikolai Kuznetsov Source Type: research