Valproate-induced Hyperammonemic Encephalopathy (VHE) in General Hospital Patients with one or more Psychiatric Disorders ☆

Divalproex sodium/valproic acid (VPA) is an antiepileptic drug approved for use in epilepsy and bipolar disorder. Valproate-induced hyperammonemia (VHA) occurs in up to 50 % of VPA-treated patients, some of which may become encephalopathic. Valproate-induced encephalopathy (VHE) is thought to be rare, and for a variety of reasons the diagnosis requires a high index of suspicion. The study ’s goals are to determine how common VHE is, and the quality of treatment provided when diagnosed.
Source: Psychosomatics - Category: Psychiatry & Psychology Authors: Tags: Original Article Source Type: research

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Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
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Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Conclusions: These findings suggest that carnitine deficiency is associated with the VPA dose and the serum VPA level in patients with bipolar disorder. However, it is unlikely that carnitine deficiency is associated with hyperammonemia in patients with bipolar disorder.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
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Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
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Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
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Source: Tijdschrift voor Psychiatrie - Category: Psychiatry Authors: Tags: Tijdschr Psychiatr Source Type: research
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Not Crazy Podcast Psychiatry Treatment Source Type: blogs
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Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
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