Affection of the Respiratory Muscles in Combined Complex I and IV Deficiency.

CONCLUSION: Mitochondrial myopathy due to a combined complex I+IV defect with predominant affection of the extra-ocular muscles may progress to involvement of the limb-girdle, axial and respiratory muscles resulting in muscular respiratory insufficiency. In patients with mitochondrial myopathy, neuropathy and elevated cerebrospinal fluid protein, immunoglobulins may be beneficial even for respiratory functions. PMID: 28217183 [PubMed - in process]
Source: The Open Neurology Journal - Category: Neurology Tags: Open Neurol J Source Type: research