Restoring CFTR Function Reduces Airway Bacteria and Inflammation in People With Cystic Fibrosis and Chronic Lung Infections.

CONCLUSIONS: Ivacaftor caused marked reductions in sputum P. aeruginosa density and airway inflammation and produced modest improvements in radiographic lung disease in subjects with G551D-CFTR mutations. However, P. aeruginosa airway infection persisted. Thus, measures that control infection may be required to realize the full benefits of CFTR-targeting treatments.
PMID: 28222269 [PubMed - as supplied by publisher]

Source: Am J Respir Crit Car... - February 20, 2017 Category: Intensive Care Authors: Hisert KB, Heltshe SL, Pope C, Jorth P, Wu X, Edwards RM, Radey M, Accurso FJ, Wolter DJ, Cooke G, Adam RJ, Carter S, Grogan B, Launspach JL, Donnelly SC, Gallagher C, Bruce JE, Stoltz D, Welsh MJ, Hoffman LR, McKone EF, Singh PK Tags: Am J Respir Crit Care Med Source Type: research