Calcium Channels in Vascular Smooth Muscle.

Calcium Channels in Vascular Smooth Muscle. Adv Pharmacol. 2017;78:49-87 Authors: Ghosh D, Syed AU, Prada MP, Nystoriak MA, Santana LF, Nieves-Cintrón M, Navedo MF Abstract Calcium (Ca(2+)) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca(2+) concentration ([Ca(2+)]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca(2+)-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca(2+)]i. In this review, we discuss the major Ca(2+)-permeable channels expressed in VSM and their contribution to vascular physiology and pathology. PMID: 28212803 [PubMed - in process]
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research