State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261

Conclusion and Implications IC261 inhibits sodium channels at a similar concentration necessary to reduce CK1 δ/ε activity by 50% (IC50 value 1  μM). Thus, inhibition of sodium channels might contribute to the antitumor activity of IC261.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research