Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis.

CONCLUSIONS: Electrolyte concentrations and buffer constituents of resuscitation fluids can modulate hepatic cytokine production and leukocyte recruitment in septic mice, while the effects of albumin are modest during early sepsis. Therefore, crystalloid fluid choice should be an important consideration for resuscitation in sepsis, and the effects of fluid composition on inflammation in other organ systems should be studied to better understand the physiological impact of this vital sepsis therapy. PMID: 28105603 [PubMed - in process]
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Intensive Care Med Exp Source Type: research