Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

Conclusions
Observations suggest that that peripheral TPH inhibitors uncouple the positive linkage of enterochromaffin cell-derived 5-HT to intestinal inflammation. Because peripheral TPH inhibitors evidently do not enter the murine ENS, they lack deleterious effects on constitutive intestinal motility in mice.

Source: Gut - May 5, 2014 Category: Gastroenterology Authors: Margolis, K. G., Stevanovic, K., Li, Z., Yang, Q. M., Oravecz, T., Zambrowicz, B., Jhaver, K. G., Diacou, A., Gershon, M. D. Tags: Neurogastroenterology Source Type: research