Effect of Sacubitril/valsartan on natriuretic peptides – Cardiology MCQ
Effect of Sacubitril/valsartan on natriuretic peptides is:
a) Decrease in BNP and NT-proBNP
b) Increase in BNP and NT-proBNP
c) Increase in BNP and decrease in NT-proBNP
d) Decrease in BNP and increase in NT-proBNP
Correct answer: c) Increase in BNP and decrease in NT-proBNP
Both BNP and NT-proBNP are natriuretic peptides which are increased in heart failure. Angioensin receptor neprilysin inhibitor (ARNI) Sacubitril/Valsartan improves heart heart failure and thereby decreases NT-proBNP levels. But by way of neprilysin inhibition, degradation of BNP is reduced and BNP level tends to rise [1]
Reference
1. Zile MR et al. Prognostic Implications of Changes in N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Heart Failure. J Am Coll Cardiol. 2016;68(22):2425-2436.
Source: Cardiophile MD - Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs