Abstract B08: Retinoblastoma protein orchestrates cellular apoptosis in non-small cell lung cancer in response to CDK4/6 inhibition: novel targets and key mechanisms

Conclusion: Data from multiple isogenic NSCLC models demonstrate that RB activation via CDK4/6 inhibitors results in apoptosis in an RB dependent manner. Mechanistically, RB represses transcription of multiple IAPs (including FOXM1 and Survivin), which allows pro-apoptotic factors such as SMAC to activate Caspase-3. These findings suggest that CDK4/6 inhibitors should be viewed as cytotoxic, as opposed to purely cytostatic, agents and warrant further clinical investigation.Citation Format: Chellappagounder Thangavel, Ettickan Boopathi, Yi Liu, Alex Haber, Maryna Perepelyuk, Sankar Addya, Sunday Shoyele, Adam P. Dicker, Karen E. Knudsen, Robert B. Den. Retinoblastoma protein orchestrates cellular apoptosis in non-small cell lung cancer in response to CDK4/6 inhibition: novel targets and key mechanisms. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Cancer Cell Cycle - Tumor Progression and Therapeutic Response; Feb 28-Mar 2, 2016; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(11_Suppl):Abstract nr B08.

Source: Molecular Cancer Research - November 9, 2016 Category: Cancer & Oncology Authors: Thangavel, C., Boopathi, E., Liu, Y., Haber, A., Perepelyuk, M., Addya, S., Shoyele, S., Dicker, A. P., Knudsen, K. E., Den, R. B. Tags: Rb Bench to Bedside: Novel Functions and Clinical Implications: Poster Presentations - Proffered Abstracts Source Type: research