10 Common Mistakes in the Management of Lupus Nephritis10 Common Mistakes in the Management of Lupus Nephritis

Are the most common ways to treat lupus nephritis necessarily the most effective and the safest? This new study takes a look. American Journal of Kidney Diseases
Source: Medscape Nephrology Headlines - Category: Urology & Nephrology Tags: Nephrology Journal Article Source Type: news

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This study included 45 lupus patients fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria: 25 patients with active LN during activity and during follow up (3 months later) as [group A] and 20 patients without any signs of activity [group B]. (20) age and sex matched healthy subjects were enrolled as control group [group C]. Urine samples were collected at baseline and at follow up. Urinary IP-10 and sCD25 were measured by ELISA.ResultsUrinary IP-10 and sCD25 levels were higher in group A compared to groups B and C (P 
Source: Alexandria Journal of Medicine - Category: General Medicine Source Type: research
This study aims to characterize the phenotypes of MPs and monocyte subsets in LN patients and to determine their potential to discriminate between SLE patients with and without LN. Blood and urine samples from SLE patients were collected. In monocyte subsets from whole blood samples several phenotypic markers were evaluated. MPs were isolated from platelet-poor plasma and urine by centrifugation. This phenotypic marker characterization was performed using multiparametric flow cytometry. We observed that patients with active LN have lower counts of non-classical monocytes than do those without renal involvement. All monocyt...
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Eur J Immunol Source Type: research
CONCLUSIONS: Patients with SLE are similar candidates to KT than that with other immunological kidney diseases. There was no recurrence of the disease in any patient. PMID: 30502305 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect virtually any organ. Chylous ascites as a presenting manifestation of SLE has been described in a handful of cases in adults. However, to the best of our knowledge this presentation has never been reported in the pediatric age group. Podocytopathy in SLE was initially considered to be a chance association. However, more recently it has been suggested that minimal change disease is not only a chance association; it is part of the lupus nephritis spectrum. PMID: 30526330 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
CONCLUSION: Mold infection tended to develop in patients with active lupus disease with high mortality. Co-infection is not rare. Lymphopenia and an accumulated dose of glucocorticoid are associated with invasive fungal disease in lupus patients. PMID: 30526329 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
AbstractObjectiveWhether maintaining steroid-free remission is feasible in Indian patients with systemic lupus erythematosus (SLE).MethodsIn 148 patients with SLE including 78 lupus nephritis (LN) previously put into remission, steroid therapy was gradually tapered off.ResultsPatients received glucocorticoids for median 1855  days (interquartile range (IQR) 901–2834) before discontinuing. Median duration of follow-up was 539 days (IQR 266.25–840.75). Flare occurred in 31 patients (20.9%; 95% confidence interval (CI) 15.17–28.19, renal flare in 12.16% (18/148, 95% CI 7.83–18.41)). Most of t...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractObjectiveto appraise the role of epitope spreading in established human systemic lupus erythematosus (SLE).MethodsIgG ‐autoantibody reactivity to 398 distinct recombinant proteins was measured in 69 SLE patients over 6 years and compared to 45 controls. Changes in mean fluorescence intensity (MFI), number of autoantibodies to distinct antigens, and reactivity to distinct clones of selected established antigenic t argets U1‐RNP, Sm, and ribosomal P representing epitope fine mapping were assessed. Linear mixed modelling adjusted for age and sex with Bonferroni correction was applied.ResultsThe total number of aut...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
(MedPage Today) -- Results from AURA-LV trial in patients with active disease
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
Authors: Pinheiro SVB, Dias RF, Fabiano RCG, Araujo SA, Silva ACSE Abstract Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations seen in individuals with systemic lupus erythematosus (SLE). LN is more frequent and severe in pediatric patients and has been associated with higher morbidity and mortality rates. This narrative review aimed to describe the general aspects of LN and its particularities when affecting children and adolescents, while focusing on the disease's etiopathogenesis, clinical manifestations, renal tissue alterations, and treatment options. PMID:...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Publication date: Available online 22 November 2018Source: Pharmacological ResearchAuthor(s): Yalda Rahbar Saadat, Mina Hejazian, Milad Bastami, Seyed Mahdi Hosseinian Khatibi, Mohammadreza Ardalan, Sepideh Zununi VahedAbstractSystemic lupus erythematosus (SLE) is a complex, inflammatory, and autoimmune disease triggered by complicated interactions of different factors. A major contributor to morbidity and mortality in SLE is lupus nephritis (LN). To date, the cause of SLE and LN is incompletely understood but a combination of genetic and environmental factors is thought to be involved. In recent years, there have been att...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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