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10 Common Mistakes in the Management of Lupus Nephritis10 Common Mistakes in the Management of Lupus Nephritis

Are the most common ways to treat lupus nephritis necessarily the most effective and the safest? This new study takes a look. American Journal of Kidney Diseases
Source: Medscape Nephrology Headlines - Category: Urology & Nephrology Tags: Nephrology Journal Article Source Type: news

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by inflammation of organs systems in the body. Active SLE can put a patient at risk for life-threatening complications such as lupus nephritis (LN), an inflammation of the kidneys that can cause permanent, irreversible organ damage. LN can mimic other illnesses, and medical management may be challenging. The purpose of this article is to aid nurse practitioners in identifying and managing LN as a complication of SLE to provide safe and quality care to patients.
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: Continuing Education Source Type: research
AbstractBackgroundThe incidence and age distribution of membranoproliferative glomerulonephritis (MPGN) vary throughout the world by race and ethnicity. We sought to evaluate the clinical features, pathogenesis, and age distribution of MPGN among a large nationwide data from the Japan Renal Biopsy Registry (J-RBR).MethodsA cross-sectional survey of 593 patients with MPGN (types I and III) registered in the J-RBR between 2007 and 2015 was conducted. Clinical parameters, and laboratory findings at diagnosis were compared between children (
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE).
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Few data has been available on the effect of serum HDL-C levels on the prognosis of lupus nephritis (LN) patients. The present study therefore aimed to explore the effect of serum HDL-C levels on LN patients.
Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
ConclusionThe present study might suggest that ACE I/D polymorphism may be a genetic molecular marker to predict SLE, while this polymorphism may not correlate with LN susceptibility.
Source: APLAR Journal of Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Abstract Severe lupus nephritis in the absence of systemic lupus erythematosus (SLE) is a rare condition with an unclear clinical presentation and outcome. We conducted a historical observational study of 12 adult (age>18 years) patients with biopsy-proven severe lupus nephritis or lupus-like nephritis without SLE immunological markers at diagnosis or during follow-up. Excluded were patients with chronic infections with HIV or hepatitis B or C; patients with a bacterial infectious disease; and patients with pure membranous nephropathy. Electron microscopy was retrospectively performed when the material was available....
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
A 24-year-old man presented to the emergency department with a 2-day history of progressively worsening chest pain and shortness of breath. He described the pain as a sharp, substernal sensation occurring at rest, exacerbated by deep inspiration or lying flat on his back, and alleviated by sitting upright leaning forward. He did not report radiation to the neck or left arm. Associated symptoms included nausea, vomiting, and nonproductive cough, which began 2 days before the onset of chest pain. His medical history was notable for systemic lupus erythematosus (SLE) complicated by nephritis and congestive heart failure with ...
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents' clinic Source Type: research
Source: Journal of the American Society of Nephrology : JASN - Category: Urology & Nephrology Authors: Tags: Editorials Source Type: research
Our previous studies showed that multitarget therapy is superior in efficacy to intravenous cyclophosphamide as an induction treatment for lupus nephritis in Asian populations. We conducted an open label, multicenter study for 18 months as an extension of the prior induction therapy trial in 19 renal centers in China to assess the efficacy and safety of multitarget maintenance therapy in patients who had responded at 24 weeks during the induction phase. Patients who had undergone multitarget induction therapy continued to receive multitarget therapy (tacrolimus, 2–3 mg/d; mycophenolate mofetil, 0.50–0.75 g/d; p...
Source: Journal of the American Society of Nephrology : JASN - Category: Urology & Nephrology Authors: Tags: Clinical Research Source Type: research
Abstract ObjectiveWhile systemic lupus erythematosus (SLE) and lupus nephritis (LN) disproportionately affect females, prior studies suggest that males may experience poorer outcomes. We investigated sex differences in healthcare utilization, end‐stage renal disease (ESRD) and mortality among patients with LN receiving Medicaid, public insurance for low‐income individuals. MethodsWithin Medicaid Analytic eXtract (MAX) from 29 states (2000‐2010), we used billing claims to identify individuals 5‐65 years with incident LN (PPV 80%). MAX data were linked to the US Renal Data System to determine ESRD, and to Social Secu...
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Tags: Full Length Source Type: research
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