Prepregnancy diabetes, hyperglycaemic status, and adverse pregnancy outcomes in Chinese women: a population-based mega-cohort study

This study was approved by the Institutional Research Review Board at the National Health and Family Planning Commission and National Research Institute for Family Planning. Written informed consent in Chinese was obtained from all participants or their legal representatives. Findings 79 686 preterm births, 15 354 cases of low birthweight, and 33 667 cases of macrosomia were recorded. Compared with women whose blood glucose was less than 6·1 mmol/L before pregnancy, the risk of preterm birth was increased for those with impaired fasting glucose (OR 1·08, 95% CI 1·03–1·13) and those with diabetes (1·15, 1·08–1·22; ptrend<0·0001). The ORs of low birthweight were 1·16 (1·06–1·27) for women with impaired fasting glucose and 1·10 (0·97–1·26) for those with diabetes (ptrend=0·0023). The ORs of macrosomia were 1·00 (0·93–1·08) for those with impaired fasting glucose and 1·20 (1·09–1·31) for those with diabetes (ptrend<0·0001). Interpretation Prepregnancy diabetes and impaired fasting glucose are associated with an increased risk of adverse pregnancy outcomes. Therefore, early screening and preconception care for women with diabetes and impaired fasting glucose are important for optimisation of pregnancy outcomes. Funding Five-twelfth National Science and Technology Support Program.
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research