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Arthritis drug boosts effectiveness of antidepressant medication

Giving severely depressed patients the arthritis drug celecoxib (Celebrex ®) dramatically boosted the effectiveness of their antidepressant medication, a new study has found.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Mainstream doctors are quick to prescribe drugs to bring high blood pressure down.  They may put you on one, two or even three of Big Pharma’s drugs. They include diuretics, beta-blockers, and calcium channel blockers.   These drugs have serious side effects. I’m talking about things like edema, dizziness, nose bleeds, rash and hearing loss. They can lead to cardiac failure, heart attack, depression, colitis, and arthritis pain.  It’s bad enough risking those side effects if you have to. But your doctor may be giving you these pills for NO good reason. You mi...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Source Type: news
Publication date: November 2017 Source:Brain, Behavior, and Immunity, Volume 66 Author(s): Yu Sun, Dai Wang, Giacomo Salvadore, Benjamin Hsu, Mark Curran, Corey Casper, Jessica Vermeulen, Justine M. Kent, Jaskaran Singh, Wayne C. Drevets, Gayle M. Wittenberg, Guang Chen Cytokines, including interleukin-6 (IL-6), modulate neuronal plasticity and stress coping. Depressive symptoms and major depressive disorder (MDD) have been associated with changes in cytokines and their signaling. The current study examined the effect of IL-6 monoclonal antibody administration on depressive symptoms in patients with rheumatoid arthritis (...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Conclusion Although RA complicated by depression may be related to the following high disease activity, a poor QOL and poor ADLs, the serum OXT levels were not directly correlated. PMID: 29021442 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
In August, The New York Times published a guest op-ed by a man named David Roberts who suffered from severe chronic pain for many years before finally finding relief. The piece immediately went viral, with distinguished news journalist and personality Dan Rather posting it to his Facebook page with the addendum that it could “offer hope” to some pain patients. However, for many of us in the chronic pain community, particularly women, the piece was regarded with weariness and frustration. The first and most prominent source of annoyance for me regarding this piece was the part when the author finally discloses h...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Behavioral Health Pain Management Women's Health Source Type: blogs
ConclusionOcular and oral dryness sensitivity can be classified on a continuous scale. The 2 symptom types are predicted by different variables. A large number of factors remain to be explored that may impact symptom sensitivity in primary Sjögrenʼs syndrome, and the proposed method could be used to identify relatively sensitive and stoical patients for future studies.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Authors: Castrejón I, Chua JR, Pincus T Abstract A physician global assessment of patient status (DOCGL) was designed initially to quantitate inflammatory activity in rheumatoid arthritis (RA) clinical trials, in which patients are selected for high levels of activity. However, in patients seen in routine care with various diagnoses, and even in some RA patients selected for clinical trials, DOCGL also may be affected by joint damage and/or patient distress. To clarify DOCGL on a 0-10 visual analogue scale (VAS), 3 additional 0-10 VAS have been developed to record physician estimates of inflammation (DOCINF)...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Hawker GA Abstract Musculoskeletal (MSK) pain has a major impact on people's quality of life. Chronic MSK pain causes sleep interruption, fatigue, depressed mood, activity limitations and participation restrictions. The impact of MSK pain is influenced by contextual factors, including comorbidity, arthritis coping efficacy and access to MSK care. Thus, MSK pain assessment warrants a bio-psychosocial perspective that includes pain, its downstream effects and contextual factors. Such an approach should incorporate elicitation of symptoms using patient-report questionnaires and physical examination to help lo...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
CONCLUSION: Psychosocial factors have additional effects on DAS throughout the first year of treatment in early RA. A change was observed from anxiety and coping with pain at baseline being associated with subsequent DAS towards fatigue being associated with subsequent DAS at 12 months. Owing to the explorative nature of this study, more research is needed to confirm this pattern. PMID: 28967272 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
The prevalence of depression in patients with rheumatoid arthritis (RA) is estimated to be 3.5 times that of the general population and even higher than those with other chronic diseases. However, in Korea, there is still unmet needs in nation-wide data. Thus, this study aims to explore the prevalence of depression in patients with RA according to various definitions of depression and RA severity using the Health Insurance Review and Assessment service (HIRA) claims database in 2014.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
Determine whether the four-factor structure of the Medication Adherence Reasons Scale (MAR-Scale) is replicated in additional comorbid conditions.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
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