JCI online ahead of print table of contents for April 17, 2014

(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, April 17, 2014 in the JCI: 'Double-stapled peptide inhibits RSV infection,' 'Fibroblast-derived exosomes mediate caridiomyocyte hypertrophy via microRNA delivery,' 'Patient response to cryptococcosis is dependent on fungal-specific factors,' 'The coinhibitory receptor PD-1H suppresses T cell responses,' 'Type-1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis,' and more.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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In this study, we investigated the antifungal potential of fenbendazole, the most effective anti-cryptococcal benzimidazole. Fenbendazole was inhibitory against 17 different isolates of C. neoformans and C. gattii at a low concentration. The mechanism of anti-cryptococcal activity of fenbendazole involved microtubule disorganization, as previously described for human parasites. In combination with fenbendazole, the concentrations of the standard antifungal amphotericin B required to control cryptococcal growth were lower than those required when this antifungal was used alone. Fenbendazole was not toxic to mammalian cells....
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
ConclusionsCryptococcosis develops in various organs. Typical radiological manifestation accompanied with positive serum CrAg provides helpful clues for the diagnosis. Lumbar puncture is a critical diagnostic method to distinguish CM. The accumulated dose of GC is associated with cryptococcosis in patients with CTD.Key Points•Pulmonary cryptococcosis is suspected if pulmonary nodules adjacent to the pleura are present, with serum CrAg positive.•Cryptococcal meningitis has insidious onset and the diagnosis mainly depends on lumber puncture.•Cryptococcal sepsis is not rare and needs timely blood culture in suspected patients.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 31 March 2020Source: Medical Mycology Case ReportsAuthor(s): Miglė Jarašūnienė, Emilija Šerpytienė, Justina Mackevičiūtė, Jonas Lauraitis, Jūratė Grigaitienė
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
Conclusions and significanceFluconazole MIC50 and MIC90 values were two-fold higher in 2017 compared to 2007 –2008. Although there are no breakpoints, higher fluconazole doses may be required to maintain efficacy of standard treatment regimens for cryptococcal meningitis.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Early cryptococcal disease can be detected via circulating antigen in blood before fulminant meningitis develops, when early antifungal therapy improves survival. Two semiquantitative cryptococcal antigen (CrAg) lateral flow assays (LFAs) have been developed, but their diagnostic performance has not been defined. Cryopreserved serum samples from HIV-infected Ugandans obtained as part of a prospective CrAg-screening cohort were tested in duplicate for CrAg by the CrAgSQ (IMMY) and CryptoPS (Biosynex) lateral flow assays. Case-controlled diagnostic performance was measured using the FDA-approved CrAg LFA (IMMY) as a referenc...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Mycology Source Type: research
Authors: Esteller D, Llansó L, Escoda O PMID: 32173074 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Kano R, Sugita T, Kamata H Abstract Ravuconazole (RVCZ) is a newly available human azole drug in Japan since 2018 and is a broad-spectrum antifungal agent that exhibits excellent activity against Candida albicans and Cryptococcus neoformans (formerly: Cryptococcus grubii). The drug is also highly active against isolates that are resistant to fluconazole (FLCZ). In the present study, the in vitro susceptibility to ravuconazole (RVCZ) of Japanese clinical isolates and multi-azole-resistant strains of C. neoformans was investigated using the Clinical &Laboratory Standards Institute (CLSI) M27-A3 test. The...
Source: Medical Mycology Journal - Category: Biology Tags: Med Mycol J Source Type: research
Publication date: Available online 3 March 2020Source: Respiratory Medicine Case ReportsAuthor(s): Rahul Bollam, Mohamed Yassin, Tung Phan
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
We present an immunocompetent patient with disseminated cryptococcosis and extensive bone marrow involvement.
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
Publication date: Available online 22 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Mohammad Hossein Harirchian, Maryam Poursadeghfard, Alireza Sadeghipour, Hoda Kamali, Payam SarrafAbstractFingolimod has been the first approved oral medication in MS for its relapsing remitting type. It is a non-selective sphingosine1-phosphate (S1P) receptor modulator on lymphocytes. Engagement of this receptor blocks the T cells and B cells migration from the lymph nodes into the inflamed central nervous system (CNS) via bloodstream. In spite of this known immunomodulatory mechanism, there are some reports about...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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