Stem Cells Seen as Promising in Lupus (CME/CE)

(MedPage Today) -- Mesenchymal stem cell transplantation is showing promise as a treatment for refractory systemic lupus erythematosus, researchers have reported.
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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AbstractTo analyze the clinical characteristics of severe thrombocytopenia in patients with various connective tissue diseases (CTDs), one hundred thirty-one consecutive CTD patients with blood platelet count less than 20  × 109/L on admission, which was ascribed to the nature of diseases, during January 2011 to June 2015 in our department were enrolled and checked for their survival status in September 2015. The patients were categorized based on background diseases or therapeutic effects, and compared with clinical features, treatment strategies, and long-term outcomes among the groups. Cumulative sur...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Abstract Lupus nephritis (LN), a common manifestation of systemic lupus erythematosus (SLE), accounts for significant morbidity and mortality in SLE patients. Since the available standard therapies and biologic agents for LN are yet to achieve the desired response and have considerable secondary effects, stem cell therapy has now emerged as a new approach. This therapy involves the transplantation of hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Our current review will highlight the progress of stem cell therapy for LN, along with the challenges encountered and the future direction of this app...
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
Erratum corrige: "Autologous peripheral blood haematopoietic stem cell transplantation for systemic lupus erythematosus:the observation of long-term outcomes in a Chinese centre". C. Cao et al. Clin Exp Rheumatol. 2018 Jul-Aug;36(4):688 Authors: Cao C, Wang M, Sun J, Peng X, Liu Q, Huang L, Chai Y, Lai K, Chen P, Liu Q, Li Q, Peng Y, Xiong H, Zhang J, Chen M, Zeng K PMID: 30058528 [PubMed - in process]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Nelly M. Cruz, Benjamin S. FreedmanCRISPR is a nuclease guidance system that enables rapid and efficient gene editing of specific DNA sequences within genomes. We review applications of CRISPR for the study and treatment of kidney disease. CRISPR enables functional experiments in cell lines and model organisms to validate candidate genes arising from genetic studies. CRISPR has furthermore been used to establish the first models of genetic disease in human kidney organoids derived from pluripotent stem cells. These gene-edi...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Conditions:   Lupus Erythematosus;   Stem Cell Transplant Intervention:   Biological: mesenchymal stem cells Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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