Two new triterpenoid saponins from the roots of Albizia zygia (DC.) J.F. Macbr.

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Olivier Placide Noté, Line Simo, Joséphine Ngo Mbing, Dominique Guillaume, Sarah Ali Aouazou, Christian Dominique Muller, Dieudonné Emmanuel Pegnyemb, Annelise Lobstein As part of our search of new apoptosis-inducing triterpenoid saponins from Cameroonian Albizia genus, phytochemical investigation of the roots of Albizia zygia led to the isolation of two new oleanane-type saponins, named zygiaosides A–B (1–2), together with two known saponins, coriarioside A (3) and lebbeckoside A (4). Their structures were established on the basis of extensive 1D and 2D NMR (1H, 13C NMR, DEPT, COSY, HSQC-TOCSY, NOESY, HSQC and HMBC) and HRESIMS studies, and by chemical evidence. The apoptotic effect of saponins 1–2 was evaluated on the A431 human epidermoid cancer cell. Cytometric analyses showed that saponins 1–2 induced apoptosis of human epidermoid cancer cell (A341) in a dose-dependent manner. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research