Pas de Deux
AbstractIn this personal essay, Mark Osteen uses the metaphor of apas de deux to dramatize how caring for his autistic son has enriched his scholarship and teaching. In his early years as the father of an autistic child, Osteen ’s parental and professional roles clashed, but gradually he learns to use what his son teaches him—particularly about nonverbal communication and multiple forms of intelligence—to develop a theory of empathetic scholarship and to enhance his pedagogy.
Authors: Falougy HE, Filova B, Ostatnikova D, Bacova Z, Bakos J Abstract Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both s...
At least a dozen children diagnosed with autism were conceived with sperm from the same donor.
DISCUSSION: Data demonstrate that ASD behaviors may seem de novo of degenerative dementia and such behaviors are more prevalent in those with early onset dementia. Further work elucidating a connection between ASD and dementia could shed light on subclinical forms of ASD, identify areas of shared neuroanatomic involvement between ASD and dementias, and provide valuable insights that might hasten the development of therapeutic strategies. PMID: 31517641 [PubMed - as supplied by publisher]
Publication date: October 2019Source: Molecular Immunology, Volume 114Author(s): Sheikh F. Ahmad, Ahmed Nadeem, Mushtaq A. Ansari, Saleh A. Bakheet, Haneen A. Al-Mazroua, Mohammad R. Khan, Abdullah F. Alasmari, Wael A. Alanazi, Homood M. As Sobeai, Sabry M. AttiaAbstractAutism is a neurodevelopmental disorder characterized by deficits and qualitative impairments in communication and implicit skill learning. Its prevalence is higher than previous estimates, and treatments have limited efficacy and are costly. Here, we assessed the therapeutic potential of JNJ77777120 (JNJ), a histamine-4 receptor (H4R) antagonist, using BTB...
A new study from the University of Colorado Boulder has found that autism rates rose 73% among Hispanics and 44% among blacks in children born between 2007 and 2013.
Conditions: Autism; Autism Spectrum Disorder Interventions: Biological: Cord Tissue Mesenchymal Stromal Cells; Other: Placebo Infusion Sponsors: Joanne Kurtzberg, MD; The Marcus Foundation Not yet recruiting
Abstract Despite the rising interest in intervention for children with autism spectrum disorder, the extent to which interventions are effective on gross motor outcomes is currently unknown. The purpose of this study was to analyze the effect of different intervention approaches on gross motor outcomes among children with autism spectrum disorder using meta-analysis. A total of 18 studies met the inclusion criteria for quantitative analysis. Pre- and posttest means and SDs were extracted to calculate effect sizes. Potential moderator variables were chosen based on important intervention characteristics. The result...
ConclusionsThe RDI is an effective quantitative metric of developmental deviance/difference that correlates with ASD traits, supporting previous associations between ASD and non-sequential skill acquisition. The RDI can be adapted to other clinical measures to investigate the degree of difference that is not captured by standard performance summary scores.
ConclusionsThe current work addresses the importance of studying the development of psychopathology in a specific neurogenetic population. Temperamental negative affect was shown to be an important early marker for anxiety in young children with FXS, with subtle differences observed between males and females.
Molecular Psychiatry, Published online: 13 September 2019; doi:10.1038/s41380-019-0524-zCorrection: Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice