H1N1 'Swine Flu' vaccine unlikely to raise birth defect risk

HealthDay News Swedish researchers report that the vaccine against the H1N1 " swine flu " strain of influenza doesn't seem to have a link to birth defects.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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We describe here that pre-exposure with a live virus generated via a A/WSN/1933(H1N1) reverse genetics system resulted in a significant reduction of viral shedding from pigs exposed to either a swine H1N1 virus or a swine H3N2 virus. At 3-day post challenge (DPC), approximately 1 log and 1.5 logs reductions of viral shedding were observed in the swine H1N1- and H3N2-challenged vaccinated pigs when compared to unvaccinated animals. A further decline in viral load was observed at 5 DPC where viral shedding was decreased by greater than 3 logs in vaccinated pigs receiving either the H1N1 or H3N2 virus challenge. Although the ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
W, Taylor C, Wentworth DE, Xu X, Zanders N, Katz J, Jernigan D Abstract During May 20-October 13, 2018,* low levels of influenza activity were reported in the United States, with a mix of influenza A and B viruses circulating. Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions. Antigenic testing of available influenza A and B viruses indicated that no significant antigenic drift in circulating viruses had emerged. In late September, the components for the 2019 Southern Hemisphere influenza vaccine were selected and included an incremen...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Publication date: Available online 8 September 2018Source: Microbial PathogenesisAuthor(s): Vladislav Victorovich Khrustalev, Tatyana Aleksandrovna Khrustaleva, Larisa Valentinovna KordyukovaAbstractThe aim of this study was to construct a vaccine peptide candidate against pandemic Influenza H1N1 hemagglutinin and to test its structure. With the help of bioinformatic algorithms we showed that the sequence encoding the second polypeptide of pandemic Influenza H1N1 hemagglutinin (HA2) is protected from nonsynonymous mutations better than the sequence encoding its first polypeptide (HA1). With the help of secondary and ternar...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In conclusion, the inactivated high-growth reassortant vaccine SH1/PR8 could induce high antibody levels and complete protection is expected against SH1 wild type SIV, and protection against heterologous EA H1N1 SIV needs further evaluation.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In this study, we screened all the protein sequences of the swine-origin epidemic IAV strain A/Beijing/01/2009 (H1N1), and a total of 73 9-mer epitope peptides were predicted to fit the consensus motif of the swine SLA-3*hs0202 or HLA-A*0201 molecule. Then, 14 peptides were selected, and their affinities to SLA-3*hs0202 were tested by a modified in vitro refolding assay. Our results show that ten epitopes could tolerate gel filtration, indicating that these epitopes formed stable or partly stable complexes with SLA-3*hs0202. Eight out of the ten epitopes have been previously reported as HLA-A2-restricted epitopes, which im...
Source: Immunogenetics - Category: Genetics & Stem Cells Source Type: research
In conclusion, the inactivated high-growth reassortant vaccine SH1/PR8 could induce high antibody levels and complete protection is expected against SH1 wild type SIV, and protection against heterologous EA H1N1 SIV needs further evaluation.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
CONCLUSIONS Despite great progress in the management of ARDS, based mostly on advanced mechanical ventilation, early antiviral treatment of pneumonia caused by influenza A (H1N1) and annual vaccinations seem essential in prevention and management of influenza A (H1N1) infection among kidney transplant recipients. PMID: 29599422 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
After a two-year hiatus, the nasal flu vaccine is set to return to doctors’ offices next year. The Advisory Committee on Immunization Practices (ACIP) voted 12 to 2 on Wednesday to return the nasal spray to the CDC’s list of recommended vaccines for the 2018-2019 flu season. Pending final approval from the CDC director, the vote would greenlight the spray for widespread use and compel insurance companies to cover it. The committee stopped short of explicitly recommending the nasal spray, however, and will instead let providers and patients decide if they’ll use it instead of traditional flu shots. There ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime medicine onetime Source Type: news
In conclusion, responses of pigs to H1N1 were affected by both the physiological development of animals at infection and the MDA level.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In this study we examined the magnitude and type of immune response induced in pigs vaccinated via the intramuscular or intradermal routes with inactivated swine influenza virus (SIV) H1N1 vaccine formulated with PCEP. Intradermal administration of PCEP-adjuvanted inactivated SIV vaccine stimulated significant anti-SIV antibody titres, increased neutralizing antibodies, and significantly reduced lung virus load with limited reduction of gross lung lesions after challenge with virulent H1N1 relative to control animals. These results indicate that PCEP may be effective as a vaccine adjuvant against swine influenza viruses in...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
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