Predictive & amp; Prognostic Implications of Variant Philadelphia Translocations in CML – Experience from a Tertiary Oncology Centre in Southern India

Conclusion This is a largest series of variant translocations in CML-CP, pertaining to Indian population. Our data suggests that presence of variant Ph translocations in CML has no significant impact in predicting response to imatinib as well as in prognosticating survival. Teaser Chronic myeloid leukemia with variant translocation in imatinib era has been an area of research regarding its predictive and prognostic effect with current treatment. Our data confirms that use of imatinib overcomes the negative prognostic effect of these translocations giving similar response rates and survival outcomes.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research