Antibacterial and Anti HIV 1 Reverse Transcriptase Activity of Selected Medicinal Plants from Phalaborwa, South Africa

Conclusion: The findings of the study indicate that studies of this nature are useful and may lead to for discovery of more plant-derived compounds with activities against bacterial and viral strains. Furthermore, the identity of the active ingredients may be important to establish the mechanisms used by some of these plants.
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Authors: Cho JC, Childs-Kean LM, Zmarlicka MT, Crotty MP Abstract Omadacycline is a novel aminomethylcycline antimicrobial agent that is available in both oral and intravenous formulations. The distinguishing structural characteristics of omadacycline from other tetracyclines allow for its continued antimicrobial activity in the presence of traditional tetracycline resistance mechanisms (efflux pumps and ribosomal protection proteins). Omadacycline has been found to have potent activity against antibiotic-resistant pathogens including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, e...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
Abstract Considering alarming projections in the prevalence of periodontitis, following study was undertaken to develop chitosan-vanillin cross-linked microspheres loaded in-situ gel (MLIG) implants containing ornidazole and doxycycline hyclate for the treatment of pocket infections. Firstly, microspheres were formulated and optimized using response surface methodology for particle size 80%, in-vitro drug release (T80%)>7 days and acceptable mucoadhesion. Further, MLIG were optimized for gelation temperature of 34-37 °C and viscosity
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Abstract Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete Streptomyces sp. G278 led to the isolation of ten compounds, 1-10. Two compounds, 2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene (1), and 3-hydroxyl-2-methylpyridine (2) were isolated from a natural source for the first time. The structures of the isolated compounds were established by their spectral data analysis, including mass spectrometry, 1D-NMR, 2D-NMR, and X-ray crystallographic analysis in case of compound 3. All isolated compounds were evaluated for their antimicrobial activity against a panel of cl...
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research
Abstract The bacteriocin enterocin-B contains broad anti-microbial spectrum against several gram positive, negative pathogenic bacteria was cloned, overexpressed and purified from Enterococcus faecium por1. The molecular weight of the bacteriocin enterocin-B was observed around 7.2 kDa and interacting, formation of heterodimer with another bacteriocin enterocin-A from the same organism by protein-protein docking and molecular dynamics simulation studies. The heterodimer of bacteriocin enterocin-A + B exhibited potential anti-bacterial, anti-biofilm activity against Staphylococcus aureus, Listeria monocytogen...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
CONCLUSION: With the best in vitro activity among the tested antibiotics, fosfomycin could be an effective treatment option for infections caused by multiresistant Gram-negative and Gram-positive bacterial strains in the hospital setting. PMID: 29740989 [PubMed - in process]
Source: Croatian Medical Journal - Category: General Medicine Authors: Tags: Croat Med J Source Type: research
CONCLUSIONS: The leaf extract of O. aristatus and W. floribunda exhibited a significant anti-candidal effect. Therefore, both of these plants can serve as prospective source materials for the development of new anti-candidal agents. PMID: 29656672 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Publication date: Available online 10 April 2018 Source:Journal of Hospital Infection Author(s): Beatriz Alonso, María Jesús Pérez-Granda, Ana Rodríguez-Huerta, Carmen Rodríguez, Emilio Bouza, María Guembe Ethanol-based lock therapy (LT) solutions are used as an alternative to antibiotics for the conservative management of catheter-related bloodstream infection. However, no clear consensus on regimen or dose has been reached. Our objective was to find the ethanol-based lock solution containing a sufficiently low concentration of ethanol for reduction of the metabolic activity of b...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Authors: Kaambo E, Africa CWJ Abstract Aerobic vaginitis (AV) is an endogenous opportunistic infection brought about by the disruption of the normal vaginal microbiota. Its early diagnosis and treatment during pregnancy may reduce the risk of negative pregnancy outcomes. The aim of this review was to report on the aerobic bacteria most prevalent in AV and to provide evidence of the threat of untreated AV on pregnancy outcomes. More than 300 papers on preterm delivery were extracted from several research domains and filtered to include only AV-associated bacteria such as Staphylococcus aureus, Enterococcus faecalis,...
Source: African Journal of Reproductive Health - Category: African Health Tags: Afr J Reprod Health Source Type: research
Publication date: Available online 14 March 2018 Source:Microbial Pathogenesis Author(s): Juliana S. Novais, Caroline S. Moreira, Ana Carolina J.A. Silva, Raquel S. Loureiro, Agnes Marie Sá Figueiredo, Vitor F. Ferreira, Helena C. Castro, David R. da Rocha The aims of this study were the planning, synthesis and in vitro evaluation of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against Gram-negative and Gram-positive strains, searching for potential lead compounds against bacterial biofilm formation. A series of 12 new analogs of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones were synthesized by a...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Conclusion: pH of the wound environment plays a pivotal role in wound healing. Acetic acid with concentration of 1% has shown to be efficacious against wide range of bacteria as well as fungi, simultaneously accelerating wound healing. Acetic acid is non-toxic, inexpensive, easily available and efficient topical agent for effective elimination of wound infections caused due to multi-drug resistant, large variety of bacteria and fungus.
Source: Indian Journal of Plastic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
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