Aberrant p15, p16, p53, and DAPK Gene Methylation in Myelomagenesis: Clinical and Prognostic Implications

Aberrant DNA methylation is important in multiple myeloma pathogenesis. Methylation of p15, p16, p53, and DAPK genes was evaluated in bone marrow (94 patients; 8 controls) by methylation-specific polymerase chain reaction; 63% of patients with multiple myeloma and 39% of patients with monoclonal gammopathy of uncertain significance presented  ≥1 hypermethylated gene (P 

Source: Clinical Lymphoma, Myeloma and Leukemia - August 9, 2016 Category: Hematology Authors: Catarina Geraldes, Ana Cristina Gon çalves, Emília Cortesão, Marta Isabel Pereira, Adriana Roque, Artur Paiva, Letícia Ribeiro, José Manuel Nascimento-Costa, Ana Bela Sarmento-Ribeiro Tags: Original Study Source Type: research