Reoptimization of intensity-modulated proton therapy plans based on linear energy transfer

We present a treatment planning method for intensity-modulated proton therapy based on prioritized optimization, which avoids elevated LET in critical organs. The approach is demonstrated for meningiomas, base-of-skull chordomas and ependymomas where the brainstem, chiasm or optic nerve overlay the target volume.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research