Determinants of Time in Therapeutic Range in Patients Receiving Oral Anticoagulants (A Substudy of IMPACT)

Implanted cardiac arrhythmia devices can detect atrial tachyarrhythmias (atrial high-rate episodes, AHREs) that are thought to correlate with atrial fibrillation and risk of stroke. In the IMPACT trial, oral anticoagulation (OAC) was initiated when AHREs were detected by implanted cardioverter-defibrillators (ICD) and withdrawn when they abated, according to a protocol accounting both for AHRE duration as detected by remote device monitoring and stroke risk assessment. In this analysis, we ascertained determinants of time in therapeutic range (TTR) among protocol-determined vitamin K antagonist (VKA)-treated patients during the trial.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research