Limitations of clopidogrel

Slow onset of antiplatelet effect Unpredictable maximal level of platelet inhibition Wide variability of pharmacodynamic response due to: Genotype polymorphisms of enzymes needed for its intestinal absorption and conversion to active metabolite Interactions by drugs that activate or inhibit cytochrome P450
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs