Limitations of clopidogrel
Slow onset of antiplatelet effect
Unpredictable maximal level of platelet inhibition
Wide variability of pharmacodynamic response due to:
Genotype polymorphisms of enzymes needed for its intestinal absorption and conversion to active metabolite
Interactions by drugs that activate or inhibit cytochrome P450
Source: Cardiophile MD - Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology Source Type: blogs