A perspective review on role of novel NSAID prodrugs in the management of acute inflammation

Publication date: Available online 17 August 2016 Source:Journal of Acute Disease Author(s): Jaya Preethi Peesa, Prasanna Raju Yalavarthi, Arun Rasheed, Mandava Venkata Basaveswara Rao Inflammation mediators, prostaglandins are causing inflammation, pain and pyrexia in the body. Synthesis of these mediators can be effectively blocked by administering the non-steroidal anti-inflammatory drugs (NSAIDs). The NSAIDs had age-old history in medicine due to their therapeutic potentials and thus they occupy the major share in clinical practice as well as in commercial market. Mostly the NSAID moieties are chemically composed of carboxylic functional groups and this could be a potential reason for the damage of mucosal lining. Moderate and chronic oral use of these NSAIDs leads to ulcerogenicity, abdominal cramps, intestinal bleeding, mucosal hemorrhage and gastritis. Therapeutic handling of above side-effects is becoming ever challenge for the researchers. In research of surmounting side-effects caused by NSAID, prodrug approach was proven to be effective and successful. Over the time, prodrug concept becomes big boom in the arena of inflammation and its clinical treatment. In last few decades, many researchers have been attempted to synthesize the NSAID prodrugs successively. With this background of information, this article was composed and aimed to provide needful information on NSAID prodrugs such as background history, rationale, mechanism of action, principles involved and the...
Source: Journal of Acute Disease - Category: Emergency Medicine Source Type: research

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CONCLUSIONS: This meta-analysis found cardiovascular factors to be the main causes for both 30-day and 1‑year rehospitalization. Heart failure represented the most common cardiovascular event at both short-term and mid-term follow-up. Several baseline characteristics and procedure-related factors were deemed unfavorable predictors of readmission. Importantly, transfemoral access and female gender were associated with a lower risk of readmission. PMID: 31807789 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Authors: Broadhead DY, Douglas HE, Bezjian Wallace LM, Wallace PJ, Tamura S, Morgan KC, Hemler DE Abstract Back pain and its associated complications are of increasing importance among military members. The sacroiliac joint (SIJ) is a common source of chronic low back pain (LBP) and functional disability. Many patients suffering from chronic LBP utilize opioids to help control their symptoms. Platelet-rich plasma (PRP) has been used extensively to treat pain emanating from many different musculoskeletal origins; however, its use in the SIJ has been studied only on a limited basis. The patient in this case report pr...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
I am thinking about possibly doing a Psychiatry fellowship in the future and I heard some guy on Reddit mentioning "Interventional Pain Psychiatry", but I haven't been able to find any information about this fellowship online. All I found was something called "Interventional Psychiatry" where they do ECT and Ketamine infusions. What's the difference and how can I find out more information about these two? Does anyone know about these subspecialties?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
Authors: Silveira C, Guedes R, Maia D, Curral R, Coelho R Abstract Multiple Sclerosis (MS) is a chronic disabling neuroinflammatory disease. Psychiatric manifestations have a high prevalence in MS patients and may worsen the illness progression and the patients' quality of life (QoL). Depression is a highly prevalent condition in MS patients, associated with poorer adherence to treatment, decreased functional status and QoL, and increased suicide risk. Diagnosis and treatment of this disorder is challenging because of symptom overlap. Other prevalent psychiatric comorbidities are anxiety disorders, bipolar disorder...
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Publication date: Available online 7 December 2019Source: Journal of Vascular Surgery: Venous and Lymphatic DisordersAuthor(s): Elena Marín-Manzano, Covadonga Mendieta-Azcona, Luis Riera-del-Moral, Juan Carlos López-GutiérrezAbstractBackgroundVenous malformations (VMs) are the most frequent congenital vascular malformations. Pain and deformity are the main symptoms and usually progressive in untreated patients. Current therapeutic options are surgery (frequently partial resections with an uncomfortable postoperative period), sclerotherapy (often limited because of the need for high doses and the potent...
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
ConclusionWe believe that mesenteric defects should be closed after laparoscopic resection of the left side of transverse colon, regardless of their size.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionPhysicians must consider the FHH among differential diagnosis of secondary rib lesions. Surgical resection is the treatment of choice; the risk of recurrence or metastasis is neglectable.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We report a case of Russell body gastritis in a 28-year-old male who presented with abdominal pain and rectal bleeding. Endoscopy showed erosions with edema and vascular congestion in the gastric body and antrum. The biopsy showed chronic gastritis with plasma cell infiltration of the lamina propria. Many plasma cells contained cytoplasmic Russell bodies which stained positive for CD138, CD79a, Kappa and lambda light chains. The Russell bodies were negative for pancytokeratin, excluding signet ring cell carcinoma. Russell body gastritis is an uncommon, benign reactive condition. PMID: 31388200 [PubMed - in process]
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
Total pancreatectomy with islet autotransplantation (TPIAT) is a therapeutic option for debilitating acute recurrent or chronic pancreatitis. While postoperative diabetes and pain outcomes are well-described in these patients, the hematologic outcomes have not been thoroughly examined. Specifically, the natural history and optimal management of the nearly universal post-IAT extreme thrombocytosis (platelets>1000 K/μL) beginning within days of surgery and often lasting for months remains enigmatic. Concern for thrombosis risk from the extreme thrombocytosis has prompted empiric, widely-employed pharmacologic alteratio...
Source: Blood - Category: Hematology Authors: Tags: 332. Antithrombotic Therapy: Poster II Source Type: research
CONCLUSIONS: There is little or no increased suicide mortality following acute admissions for most physical illnesses. Much of the increased suicide mortality relates to gastrointestinal disorders that are often alcohol related or specific chronic conditions, which may be linked to side effects from certain therapeutic medications. Acute hospital admissions for physical illnesses may therefore provide an opportunity for targeted suicide prevention among people with certain conditions, particularly alcohol related disorders. PMID: 28714426 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
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