Subacute Toxicity Profile of the Leaves of Colocasia esculenta L. Schott in Albino Rats
This study reports the sub-acute toxicity effects of C. esculenta (CE) crude aqueous leaves extracts in albino rats. Methodology: Daily doses of 400 and 800 mg kg1 b.wt. of crude aqueous extracts of the fresh and dried leaves of CE were administered orally to different sets of rats for 28 days. Body weights, Relative Organ Weights (ROW), haematological analysis, serum biochemical assay and histopathological changes of vital organs were used to evaluate the toxic effects of the extracts after treatments. Results: Results revealed that treatment with CE causes adverse effects on body weight. The tested doses did not provoke significant changes in haematological and biochemical parameters of rats except an increase in alkaline phosphatase of treated rats (p
STOMACH bloating could be reduced by making changes to your diet. Drinking this tea could help to relieve trapped wind or constipation pain, it ’s been revealed.
CONCLUSION: This study suggests the existence of sensitive pathways inhibition by perineal contraction through a sensitive perineo-vesical inhibitory reflex. LEVEL OF EVIDENCE: 3. PMID: 29903631 [PubMed - as supplied by publisher]
Epsom salt is a widely available home remedy for many ailments, including constipation. A person can use Epsom salt as a laxative by mixing it with the right amount of water. In this article, learn how to use Epsom salt for constipation safely. We also cover the possible risks and when to see a doctor.
The prevalence of functional constipation (FC) is 3 –27%, and FC has been reported to cause discomfort in daily life and various complications. The treatment for FC depends on laxatives, and thus, effective and...
AbstractMacrogol 4000, a biologically inert, non-absorbable osmotic laxative, is a highly effective and well-tolerated first-line option for the treatment of the symptoms of chronic idiopathic/functional constipation in children and adults. High-molecular-weight (HMW) macrogols ± electrolytes have generally similar efficacy profiles; however, the taste of macrogol 4000 is generally preferred over that of macrogol 3350 + electrolytes. Macrogol 4000 is more effective than lactulose in improving stool frequency and consistency, and is associated with less vomiting a nd flatulence. Compariso...
AbstractChronic constipation is often accompanied by emotional disorders such as depression and anxiety. The aim of this study was to determine whether administration of a multispecies probiotic can decrease depressive behaviors through the gut-brain axis and identify any underlying mechanisms. A mouse model of constipation induced by loperamide (5 mg·kg−1,i.p.) was used. For that purpose, 36 ICR male mice were divided into three groups: control, constipation and probiotic groups. The probiotic group received treatment with a probiotic once per day for 14 days via a gavage. All other groups were gi...
Genetically engineered bacteria may prove to be an effective treatment for constipation after it helped treat the condition in mice, according to a new study.
In conclusion, we showed cross-sectional study of colonic MRI correlate with gastrointestinal symptoms. MRI might be useful for colonic motility evaluations to determine appropriate constipation treatments (Clinical trial registry number UMIN 000021274). PMID: 29892169 [PubMed]
This study demonstrates the therapeutic potential for targeting DOT1L in MLL-r leukemia and lays the groundwork for future combination approaches in this patient population. This clinical trial is registered at www.clinicaltrials.gov as NCT01684150.
ConclusionsLesions involving the rectum, and appearing to be neoplastic may be caused by the fungusBasidiobolus ranarum. The symptomatology and presentation may be non-specific. High levels of eosinophils in the blood, a raised ESR, and C-reactive protein may be useful pointers to the diagnosis. USG and CT scans localize the lesions and also provide a guide for biopsies. The characteristic histopathological findings are diagnostic and based on these, treatment with Itroconazole / Voriconazole is beneficial.