Subacute Toxicity Profile of the Leaves of Colocasia esculenta L. Schott in Albino Rats

This study reports the sub-acute toxicity effects of C. esculenta (CE) crude aqueous leaves extracts in albino rats. Methodology: Daily doses of 400 and 800 mg kg–1 b.wt. of crude aqueous extracts of the fresh and dried leaves of CE were administered orally to different sets of rats for 28 days. Body weights, Relative Organ Weights (ROW), haematological analysis, serum biochemical assay and histopathological changes of vital organs were used to evaluate the toxic effects of the extracts after treatments. Results: Results revealed that treatment with CE causes adverse effects on body weight. The tested doses did not provoke significant changes in haematological and biochemical parameters of rats except an increase in alkaline phosphatase of treated rats (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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An FDA panel unanimously recommended prucalopride oral tablets for the treatment of adults with chronic idiopathic constipation.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Many people have decided to try the ketogenic diet for weight loss. The most recent evidence shows that reducing your carbohydrate intake to a minimum may help you shed a few pounds, at least in the first few weeks to months. However, we don’t really know whether, over the long term, achieving and maintaining ketosis is better for weight loss than other diets. Almost any intervention can cause undesirable consequences, and the ketogenic diet is no different. One of the most well-publicized complications of ketosis is something called “keto flu.” What is keto flu? The so-called keto flu is a group of sympt...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diet and Weight Loss Health Source Type: blogs
(American Gastroenterological Association) Traditional laxatives are recommended as first-line agents to treat patients with a confirmed diagnosis of opioid-induced constipation, according to a new guideline from the American Gastroenterological Association. If an adequate trial of laxatives results in suboptimal symptom control, the guidelines recommend peripherally-acting mu-opioid receptor antagonist (PAMORA) drugs, namely naldemedine, naloxegol and methylnatrexone.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionIndian children have significantly higher stool frequency and shorter colonic transit time, which are different compared to the reported figures from  the West. Most of the Indian children with functional constipation had normal colonic transit time.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
AbstractObjectivesWe aimed to investigate the association between anorexia and sarcopenia in community dwelling older adults.MethodAnorexia was assessed by Simplified Nutritional Appetite Questionnaire (SNAQ) and sarcopenia defined by EWSGOP criteria. Study participants consisted of 442 patients from Turkish validation study of the SNAQ. Study is designed as cross-sectional in community dwelling outpatients.MeasurementsMuscle mass was determined by using bioimpedance analysis. Skeletal muscle mass index (SMMI) was calculated as SMM (kg)/height (m)2. Muscle strength was evaluated by hand grip strength (HGS) with Jamar hydra...
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
Abstract The purpose of this contribution is to evaluate the cytotoxicity and apoptosis inducing ability of structurally diverse anthraquinones to establish a relationship between structure and toxicity. Besides the wide spread use of anthraquinones in pharmacological drugs for constipation and non-prescription dietary supplements for weight loss, extracts are still commercialized as crude extracts and long-term side effects are still relevant. In this work we developed a method to quantify the cascarosides isolated from Rhamnus purshiana (Cascara Sagrada) using LC-MS/MS and evaluated the effects of this extract a...
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Tags: J Pharm Pharm Sci Source Type: research
(MedPage Today) -- FDA panel to consider two constipation drugs with backstories
Source: MedPage Today Public Health - Category: American Health Source Type: news
Conditions:   Functional Constipation;   Healthy Interventions:   Dietary Supplement: scFOS;   Dietary Supplement: Maltodextrin Sponsors:   Syral;   Biofortis Mérieux NutriSciences;   CreaBio Rhone-Alpes Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Opioid medications are some of the most commonly prescribed medications for acute and chronic pain in the United States. In 2016, nearly 92 million US adults, or approximately 38% of the population, were prescribed opioids, according to results from the National Survey on Drug Use and Health.1 As a result of the widespread use of opioids, the prevalence of opioid-related adverse effects has increased markedly. Gastrointestinal (GI) side effects, such as nausea, vomiting, gastroesophageal reflux, gastroparesis, anorexia, bloating, abdominal spasms, and constipation, are  common and collectively referred to as opioid-in...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: AGA Section Source Type: research
This document presents the official recommendations of the American Gastroenterological Association (AGA) on the medical management of opioid-induced constipation. The guideline was developed by the AGA Institute ’s Clinical Guidelines Committee and approved by the AGA Governing Board. It is accompanied by a technical review that is a compilation of clinical evidence from which these recommendations were formulated.1 Development of this guideline and its accompanying technical review was fully funded by th e AGA Institute with no additional outside funding.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: AGA Section Source Type: research
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