Subacute Toxicity Profile of the Leaves of Colocasia esculenta L. Schott in Albino Rats
This study reports the sub-acute toxicity effects of C. esculenta (CE) crude aqueous leaves extracts in albino rats. Methodology: Daily doses of 400 and 800 mg kg1 b.wt. of crude aqueous extracts of the fresh and dried leaves of CE were administered orally to different sets of rats for 28 days. Body weights, Relative Organ Weights (ROW), haematological analysis, serum biochemical assay and histopathological changes of vital organs were used to evaluate the toxic effects of the extracts after treatments. Results: Results revealed that treatment with CE causes adverse effects on body weight. The tested doses did not provoke significant changes in haematological and biochemical parameters of rats except an increase in alkaline phosphatase of treated rats (p
Discussion Gastrostomy tubes (GT or GTubes) have been used to support patients for about a century. They are placed between the abdominal skin and the stomach either percutaneously or surgically. The tubes can be a standard long tube with either a bumper or inflatable balloon internally and externally they have a retention piece to hold the GT in place. A button or low profile tube are similar but extend just beyond the skin. Reasons for GT placement include: Nutritional support Hydration maintenance Medication management Aspiration avoidance Gastric stasis decompression Obstruction bypass Quality of life improvement for...
Review in-depth clinical information, latest medical news, and guidelines about irritable bowel syndrome (IBS) and chronic constipation. Understand irritable bowel syndrome symptoms (IBS symptoms) and the clinical course of irritable bowel.
The unnamed man, 36, from Sri Lanka, suffers from multiple endocrine neoplasia type 2B, which alters bowel movements and causes 'tumour-like growths' on his tongue (pictured).
Conclusions: SNM offers an effective sustainable treatment for FI. For constipation, lasting success of SNM is limited and is thus not recommended. Reinterventions are necessary but do not impede treatment success. PMID: 30646487 [PubMed]
Conclusions: LcS supplementation improved the constipation-related symptoms in constipated subjects. Differences in baseline stool consistency could result in different anti-constipation effects of LcS intervention. LcS balanced the stool consistency-softened the HS and hardened the SS. These effects could be associated with modulation of the gut microbiota and SCFA production. PMID: 30646486 [PubMed]
Conclusions: Compared with FC patients, those with IBS-C have significantly higher distress from pelvic floor specific symptoms including POP and LUTS. Higher abdominal pain among IBS-C patients did not entirely explain these findings. A diagnosis of IBS-C and higher constipation severity correlated with PFDI-20 scores, but dyssynergia did not. PMID: 30646484 [PubMed]
Conclusion: Our study demonstrates that the new Rome IV criteria have a good agreement with the Rome III criteria for the diagnosis of FC, without an increase in the number of potential diagnoses, despite the reduction in the duration of the symptoms. This conclusion is important in the management of childhood FC, since a late diagnosis negatively affects the prognosis. PMID: 30646483 [PubMed]
Authors: Lee YJ, Park KS PMID: 30646474 [PubMed]
Parkinson ’s disease (PD) is associated with both motor and non-motor symptoms, including constipation, sensory neuropathy, depression, dementia and sleep disorder. Somatostatin (SST) is considered to be a modu...
Abstract BACKGROUND: It is unclear whether functional outcomes improve or deteriorate with age following surgery for Hirschsprung's disease. The aim of this cross-sectional study was to determine the long-term functional outcomes and quality of life (QoL) in patients with Hirschsprung's disease. METHODS: Patients with pathologically proven Hirschsprung's disease older than 7 years were included. Patients with a permanent stoma or intellectual disability were excluded. Functional outcomes were assessed according to the Rome IV criteria using the Defaecation and Faecal Continence questionnaire. QoL was assessed...