Computational Modeling of Neuronal Current MRI Signals with Rat Somatosensory Cortical Neurons

In this study, multiple neuronal morphologies of rat tissue were modeled to investigate better estimation of MRI signal change produced by neuronal magnetic field (NMF). Ten pyramidal neurons from layer II to VI of rat somatosensory area with realistic morphology, biophysics, and neuronal density were modeled to simulate NMF of neuronal tissue, from which effects of NMF on MRI signals were obtained. Neuronal current MRI signals, which consist of relative magnitude signal change (RMSC) and phase signal change (PSC), were at least three and one orders of magnitude less than a tissue with single neuron type, respectively. Also, a reduction in voxel size could increase signal alterations. Furthermore, with selection of zenith angle of external main magnetic field related to tissue surface near to 90 °, RMSC could be maximized. This value for PSC would be 90° for small voxel size and zero degree for large ones.
Source: Interdisciplinary Sciences, Computational Life Sciences - Category: Bioinformatics Source Type: research