Aberrant p15, p16, p53 and DAPK gene methylation in myelomagenesis: clinical and prognostic implications

Microabstract: Aberrant DNA methylation is important in multiple myeloma pathogenesis. Methylation of p15, p16, p53 and DAPK genes was evaluated in bone marrow (94 patients; 8 controls) by methylation-specific polymerase chain reaction. 63% of MM and 39% of MGUS presented ≥1 hypermethylated gene (p

Source: Clinical Lymphoma, Myeloma and Leukemia - August 9, 2016 Category: Hematology Authors: Catarina Geraldes, Ana Cristina Gon çalves, Emília Cortesão, Marta Isabel Pereira, Adriana Roque, Artur Paiva, Letícia Ribeiro, José Manuel Nascimento-Costa, Ana Bela Sarmento-Ribeiro Tags: Original Study Source Type: research