Post-Transplantation Natural Killer Cell Count: A Predictor of Acute Graft-Versus-Host Disease and Survival Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation

Conclusion NK cell counts after allo-HSCT, especially on day 30, were predictive of acute graft-versus-host disease, nonrelapse mortality, and survival. Serial lymphocyte subset analysis can be used to identify and treat patients at risk during the early period after allo-HSCT. Micro-Abstract Reconstitution of the immune system after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is important in transplant outcomes. We retrospectively analyzed the data from 70 patients who had undergone allo-HSCT with the lymphocyte subset results. Also, the association between the lymphocyte subset counts and early complications and outcomes after allo-HSCT was analyzed. The natural killer cell counts after allo-HSCT were predictive of acute graft-versus-host disease, nonrelapse mortality, and survival.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research