Emerging Antiepileptic Drugs for Severe Pediatric Epilepsies

This article reports the clinical trial data and personal experience in treating the severe epilepsies of childhood with the recently Food and Drug Administration-approved new antiepileptic drugs (vigabatrin, rufinamide, perampanel, and clobazam) and those in clinical trials (cannabidiol, stiripentol, and fenfluramine).
Source: Seminars in Pediatric Neurology - Category: Neurology Authors: Source Type: research

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OBJECTIVE: Posttraumatic epilepsy (PTE) is a well-described complication of traumatic brain injury (TBI). The majority of the available data regarding PTE stem from the adult population. Our aim was to identify the clinical and radiological risk factors as...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The abnormal allocation of nodules of grey matter in areas of the brain or spinal cord that should physiologically be occupied by white matter characterizes a neural defect called Grey Matter Heterotopia (GMH). The improvement of MRI techniques has enabled a deeper understanding of the neuropathological bases and epidemiology of such a condition. Among its major manifestations, there is the onset of epileptic seizures, mild intellectual disability, impairments in executive functioning, neurodevelopmental disorders; less frequently GMH has been found associated with depression, anxiety, and schizophrenia. Despite the clinic...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
The technology, tested out on patients with epilepsy who already had electrodes implanted in their brains, is currently limited to 30 –50 sentences.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Authors: Uysal SP, Sahin M Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder that is characterized by cellular and tissue dysplasia in With the advent of genetic and molecular techniques, mutations in TSC1 or TSC2 genes were discovered to be responsible for mTOR overactivation, which is the underlying mechanism of pathogenesis. TSC is a highly heterogenous clinical entity with variable presentations and severity of disease. The brain, heart, skin, eyes, kidneys, and lungs are commonly involved in this syndrome, with the neurologic symptoms comprising a significant source of mo...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
The task of epileptic focus localization receives great attention due to its role in an effective epileptic surgery. The clinicians highly depend on the intracranial EEG data to make a surgical decision related to epileptic subjects suffering from uncontrollable seizures. This surgery usually aims to remove the epileptogenic region which requires precise characterization of that area using the EEG recordings. In this paper, we propose two methods based on deep learning targeting accurate automatic epileptic focus localization using the non-stationary EEG recordings. Our first proposed method is based on semi-supervised lea...
Source: IEEE Transactions on Biomedical Circuits and Systems - Category: Biomedical Engineering Source Type: research
ConclusionPRRT2 mutations can be inherited or de novo, mainly inherited. The clinical spectrum ofPRRT2 mutation includes BIE, BFIE, ICCA, PKD, FS, and ECME. ThePRRT2‐related mutations contained point mutation, whole gene deletion and 16p11.2 deletions, and large microdeletion mutations mostly de novo. It is the first report ofPRRT2 mutation found in ECME. Our report expands the mutation and clinical spectrum ofPRRT2‐related epilepsy.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: May 2020Source: Epilepsy &Behavior, Volume 106Author(s): Anna Smith, Marte Syvertsen, Deb K. Pal
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways. Biomed Res Int. 2020;2020:6250429 Authors: Kegler A, Caprara ALF, Pascotini ET, Arend J, Gabbi P, Duarte MMMF, Furian AF, Oliveira MS, Royes LFF, Fighera MR Abstract The MnSOD Ala16Val single nucleotide polymorphism (SNP) has been associated with different diseases. However, there are scarcely studies relating this SNP in epilepsy, a neurologic disease that involves some interacting pathways, such as apoptotic and inflammatory...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusions: The most striking feature of this study was the high prevalence of incorrect diagnosis of schizophrenia, with patients not receiving the minimum correct assessment before that diagnosis, resulting in negative consequences. Caution is recommended when diagnosing severely psychotic patients independent of their acute or chronic condition. PMID: 32220147 [PubMed - as supplied by publisher]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Publication date: May 2020Source: Epilepsy &Behavior, Volume 106Author(s): Elena Zambrelli, Katherine Turner, Aglaia Vignoli, Francesca La Briola, Silvia Dionisio, Sara Malanchini, Federica Galli, Maria Paola Canevini
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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