Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia.

CONCLUSIONS: To the authors' knowledge, this is the first demonstration that excitatory synapse density is lower selectively on parvalbumin interneurons in schizophrenia and predicts the activity-dependent down-regulation of parvalbumin and GAD67. Because the activity of parvalbumin interneurons is required for generation of cortical gamma oscillations and working memory function, these findings reveal a novel pathological substrate for cortical dysfunction and cognitive deficits in schizophrenia.
PMID: 27444795 [PubMed - as supplied by publisher]

Source: The American Journal of Psychiatry - July 21, 2016 Category: Psychiatry Authors: Chung DW, Fish KN, Lewis DA Tags: Am J Psychiatry Source Type: research