Abstract < /h3 > < p class= " a-plus-plus " > There are many types of neurons that intrinsically generate rhythmic bursting activity, even when isolated, and these neurons underlie several specific motor behaviors. Rhythmic neurons that drive the inspiratory phase of respiration are located in the medullary pre-B ötzinger Complex (pre-BötC). However, it is not known..."> Abstract < /h3 > < p class= " a-plus-plus " > There are many types of neurons that intrinsically generate rhythmic bursting activity, even when isolated, and these neurons underlie several specific motor behaviors. Rhythmic neurons that drive the inspiratory phase of respiration are located in the medullary pre-B ötzinger Complex (pre-BötC). However, it is not known..." /> Abstract < /h3 > < p class= " a-plus-plus " > There are many types of neurons that intrinsically generate rhythmic bursting activity, even when isolated, and these neurons underlie several specific motor behaviors. Rhythmic neurons that drive the inspiratory phase of respiration are located in the medullary pre-B ötzinger Complex (pre-BötC). However, it is not known..." />

Modeling the effects of extracellular potassium on bursting properties in pre-B ötzinger complex neurons

< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > There are many types of neurons that intrinsically generate rhythmic bursting activity, even when isolated, and these neurons underlie several specific motor behaviors. Rhythmic neurons that drive the inspiratory phase of respiration are located in the medullary pre-B ötzinger Complex (pre-BötC). However, it is not known if their rhythmic bursting is the result of intrinsic mechanisms or synaptic interactions. In many cases, for bursting to occur, the excitability of these neurons needs to be elevated. This excitation is provided < em class= " a-plus-plus " > in vitro < /em > (e.g. in slices), by increasing extracellular potassium concentration ( < em class= " a-plus-plus " > K < /em > < sub class= " a-plus-plus " > < em class= " a-plus-plus " > out < /em > < /sub > ) well beyond physiologic levels. Elevated < em class= " a-plus-plus " > K < /em > < sub class= " a-plus-plus " > < em class= " a-plus-plus " > out < /em > < /sub > shifts the reversal potentials for all potassium currents including the potassium component of leakage to higher values. However, how an increase in < em class= " a-plus-plus " > K < /em > < sub class= " a-plus-plus " > < em class= " a-plus-plus " > out < /em > < /sub > , and the resultant changes in potassium currents, induce bursting activity, have yet to be established. Moreover, it is not known if the endogenous bursting induced < em class= " a-plus-plus " > in vitro < ...
Source: Journal of Computational Neuroscience - Category: Neuroscience Source Type: research