WT1 Mutation in Childhood Cancer
In this chapter, the role of WT1 in childhood cancer is discussed, using the key examples Wilms’ tumor, desmoplastic small round cell of childhood, and leukemia. The role of WT1 in each disease is described and mirrored to the role of WT1 in normal development.
Immune checkpoint inhibitors can be effective in patients with non-small cell lung cancer and mild interstitial lung disease, but with a greater risk.Medscape Medical News
AbstractPurposeGenetic variants may influence the pharmacokinetics and pharmacodynamics (PKPD) of cyclophosphamide (CY). CY plays a critical role in conditioning chemotherapy for hematopoietic cell transplantation (HCT), but its use is limited by toxicity. We explored the effect of genetic variants, potentially affecting PKPD of CY, and outcomes after HCT.MethodsThis observational pharmacogenomic study included 85 adults with hematologic malignancies who received reduced intensity conditioning with CY, fludarabine, and total body irradiation. We collected recipient DNA prior to HCT and evaluated 97 candidate variants in 66...
Oncogene, Published online: 27 January 2022; doi:10.1038/s41388-021-02158-wSELENOF is a new tumor suppressor in breast cancer
Dalton Trans., 2022, Accepted Manuscript DOI: 10.1039/D1DT04315C, PaperXiang Wang, Kang Song, Yong Deng, Jie Liu, Qin Peng, Xiao Lao, Jiayu Xu, Dong Wang, Turong Shi, Yuhao Li, Dan Deng, Yuqing Miao Photodynamic therapy (PDT) is an effective non-invasive treatment for tumors. The structure of the photosensitizer has an important influence on the light utilization and the efficiency of singlet-oxygen generation. In... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2022, Advance Article DOI: 10.1039/D1CC06330H, CommunicationXiao-Jie Dong, Wen-Yan Li, Qun Guan, Yan-An Li, Yu-Bin Dong A COF-based multifunctional nanomedicine CuS@COF-BDP, which can be used as a PTT/PDT bimodal therapeutic agent to inhibit cancer cell proliferation under visible- and NIR-II-light irradiation, is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
ConclusionsDecompression using a SEMS as the BTS may improve oncological outcomes over those achieved by a TDT in patients with left-sided stage II and III OCRC.
AbstractPurposePrevious studies have reported that sarcopenia increases the risk of postoperative complications following colorectal resection. This retrospective study assessed the postoperative complications of rectal resection associated with sarcopenia.MethodsWe retrospectively analyzed 262 patients who underwent curative low anterior resection for primary rectal cancer from January 2008 to May 2020 at our institution. The patients were divided into a sarcopenia group (normalized total psoas muscle area
ConclusionsBTC may develop later in children with CBD and in adults with PBM, via HDAC and AID expression and through epigenetic and genetic regulation.
ConclusionsThe risk of perioperative thrombosis in UC patients was considered similar to that in CRC, so active thromboprophylaxis should be administered to UC patients while paying attention to bleeding.Trial registrationThis study was registered with the Japanese Clinical Trials Registry as UMIN000042004 (http://www.umin.ac.jp/ctr/index.htm).
AbstractBackgroundIn addition to the direct power of anticancer drugs, the effectiveness of anticancer therapy depends on the host immune function. The present study investigated whether or not the reduction rate and histological response of preoperative chemotherapy were related to the immune microenvironment surrounding a primary tumor of the rectum.MethodsSixty-five patients received preoperative chemotherapy followed by resection from 2012 to 2014; all of these patients were retrospectively analyzed. CD3, CD8, and FoxP3 were immunohistochemically examined as markers for T lymphocytes, cytotoxic T lymphocytes, and regul...